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首页> 外文期刊>Diabetes care >Diabetes, Glycated Hemoglobin, and the Risk of Myocardial Infarction in Women and Men: A Prospective Cohort Study of the UK Biobank
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Diabetes, Glycated Hemoglobin, and the Risk of Myocardial Infarction in Women and Men: A Prospective Cohort Study of the UK Biobank

机译：糖尿病，糖化血红蛋白和妇女和男性心肌梗死的风险：英国Biobank的前瞻性队列研究

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OBJECTIVE Diabetes has shown to be a stronger risk factor for myocardial infarction (MI) in women than men. Whether sex differences exist across the glycemic spectrum is unknown. We investigated sex differences in the associations of diabetes status and glycated hemoglobin (HbA(1c)) with the risk of MI. RESEARCH DESIGN AND METHODS Data were used from 471,399 (56% women) individuals without cardiovascular disease (CVD) included in the UK Biobank. Sex-specific incidence rates were calculated by diabetes status and across levels of HbA(1c)using Poisson regression. Cox proportional hazards analyses estimated sex-specific hazard ratios (HRs) and women-to-men ratios by diabetes status and HbA(1c)for MI during a mean follow-up of 9 years. RESULTS Women had lower incidence rates of MI than men, regardless of diabetes status or HbA(1c)level. Compared with individuals without diabetes, prediabetes, undiagnosed diabetes, and previously diagnosed diabetes were associated with an increased risk of MI in both sexes. Previously diagnosed diabetes was more strongly associated with MI in women (HR 2.33 [95% CI 1.96; 2.78]) than men (1.81 [1.63; 2.02]), with a women-to-men ratio of HRs of 1.29 (1.05; 1.58). Each 1% higher HbA(1c), independent of diabetes status, was associated with an 18% greater risk of MI in both women and men. CONCLUSIONS Although the incidence of MI was higher in men than women, the presence of diabetes is associated with a greater excess relative risk of MI in women. However, each 1% higher HbA(1c)was associated with an 18% greater risk of MI in both women and men.
机译：客观糖尿病表现出对女性心肌梗死（MI）的危险因素比男性更强。在血糖谱中是否存在性别差异是未知的。我们调查了糖尿病地位和糖化血红蛋白（HBA（1C））的关联性差异，具有MI的风险。研究设计和方法从471,399名（56％的女性）个体中使用，没有心血管疾病（CVD）包括在英国Biobank中。性别特异性发病率由糖尿病状态和使用泊松回归的HBA（1c）水平计算。 Cox比例危害在平均随访期间分析了糖尿病状态和MI的HBA（1C）对估计的性别特异性危害比率（HRS）和男性对比例。结果妇女的发病率较低，而不是男性，无论糖尿病状态还是HBA（1C）水平。与没有糖尿病的个体相比，预先审查，未诊断的糖尿病和先前诊断糖尿病与两性中MI的风险增加有关。患有先前诊断的糖尿病与女性MI更强烈（HR 2.33 [95％CI 1.96; 2.78]）（1.81 [1.63; 2.02]），女性至男性的HRS为1.29（1.05; 1.58 ）。每个1％高的HBA（1C）与糖尿病身份无关，与女性和男性的MI风险大18％有关。结论虽然男性的MI发病率比女性高，但糖尿病的存在与女性中MI的相对风险较高有关。然而，每种1％的HBA（1C）与妇女和男性的MI的风险增加18％有关。

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