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首页> 外文期刊>Diabetes care >A Single Load of Fructose Attenuates the Risk of Exercise-Induced Hypoglycemia in Adults With Type 1 Diabetes on Ultra-Long-Acting Basal Insulin: A Randomized, Open-Label, Crossover Proof-of-Principle Study
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A Single Load of Fructose Attenuates the Risk of Exercise-Induced Hypoglycemia in Adults With Type 1 Diabetes on Ultra-Long-Acting Basal Insulin: A Randomized, Open-Label, Crossover Proof-of-Principle Study

机译：单次果糖减轻了在超长效基础胰岛素的1型糖尿病中诱导运动诱导的低血糖的风险：随机，开放标签，交叉的原则上的原则上研究

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摘要

OBJECTIVE While the adjustment of insulin is an established strategy to reduce the risk of exercise-associated hypoglycemia for individuals with type 1 diabetes, it is not easily feasible for those treated with ultra-long-acting basal insulin. The current study determined whether pre-exercise intake of fructose attenuates the risk of exercise-induced hypoglycemia in individuals with type 1 diabetes using insulin degludec. RESEARCH DESIGN AND METHODS Fourteen male adults with type 1 diabetes completed two 60-min aerobic cycling sessions with or without prior intake (30 min) of 20 g of fructose, in a randomized two-period crossover design. Exercise was performed in the morning in a fasted state without prior insulin reduction and after 48 h of standardized diet. The primary outcome was time to hypoglycemia (plasma glucose <= 3.9 mmol/L) during exercise. RESULTS Intake of fructose resulted in one hypoglycemic event at 60 min compared with six hypoglycemic events at 27.5 +/- 9.4 min of exercise in the control condition, translating into a risk reduction of 87.8% (hazard ratio 0.12 [95% CI 0.02, 0.66];P= 0.015). Mean plasma glucose during exercise was 7.3 +/- 1.4 mmol/L with fructose and 5.5 +/- 1.1 mmol/L in the control group (P< 0.001). Lactate levels were higher at rest in the 30 min following fructose intake (P< 0.001) but were not significantly different from the control group during exercise (P= 0.32). Substrate oxidation during exercise did not significantly differ between the conditions (P= 0.73 for carbohydrate andP= 0.48 for fat oxidation). Fructose was well tolerated. CONCLUSIONS Pre-exercise intake of fructose is an easily feasible, effective, and well-tolerated strategy to alleviate the risk of exercise-induced hypoglycemia while avoiding hyperglycemia in individuals with type 1 diabetes on ultra-long-acting insulin.
机译：目的虽然胰岛素的调整是一种规定的策略，以降低具有1型糖尿病的个体的运动相关低血糖症的风险，对于用超长作用的基底胰岛素治疗的人来说不易得到可行的。目前的研究确定了使用胰岛素Degludec的果糖预锻炼摄入量诱使患有1型糖尿病的个体中运动诱导的低血糖。研究设计和方法1型糖尿病的14名男性成人在随机的两期交叉设计中完成了两种60分钟的有氧循环术，或没有先前的摄入（30分钟）的20g果糖。锻炼在早上在禁食状态下进行，没有先前的胰岛素，并且在48小时后标准化饮食后。主要结果是在运动期间对低血糖（血浆葡萄糖<= 3.9mmol / L）的时间。结果摄入果糖导致60分钟的降血糖事件，比控制条件下运动的27.5 +/- 9.4分钟的六种降血糖事件相比，平均87.8％的风险降低（危险比0.12 [95％CI 0.02,0.66] ]; p = 0.015）。锻炼期间的平均血浆葡萄糖为7.3 +/- 1.4 mmol / L，对照组中的果糖和5.5 +/- 1.1mmol / l（p <0.001）。在果糖摄入后30分钟内乳酸水平静置较高（P <0.001），但在运动期间与对照组没有显着差异（P = 0.32）。运动期间的衬底氧化在条件下没有显着差异（用于碳水化合物ANDP = 0.48的碳水化合物0.48，用于脂肪氧化）。果糖良好耐受。结论预锻炼摄入果糖是一种易于可行，有效，耐受良好的策略，以减轻运动诱发的低血糖的风险，同时避免在超长效胰岛素上具有1型糖尿病的个体的高血糖症。

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  • 来源
    《Diabetes care》 |2020年第9期|共7页
  • 作者

    Kosinski Christophe; Herzig David; Laesser Celine Isabelle; Nakas Christos T.; Melmer Andreas; Vogt Andreas; Vogt Bruno; Laimer Markus; Bally Lia; Stettler Christoph;

  • 作者单位

    Univ Bern Univ Hosp Bern Dept Diabet Endocrinol Nutr Med &

    Metab Inselspital Bern Switzerland;

    Univ Bern Univ Hosp Bern Dept Diabet Endocrinol Nutr Med &

    Metab Inselspital Bern Switzerland;

    Univ Bern Univ Hosp Bern Dept Diabet Endocrinol Nutr Med &

    Metab Inselspital Bern Switzerland;

    Univ Thessaly Sch Agr Lab Biometry Nea Ionia Magnesia Greece;

    Univ Bern Univ Hosp Bern Dept Diabet Endocrinol Nutr Med &

    Metab Inselspital Bern Switzerland;

    Univ Bern Univ Hosp Bern Inselspital Dept Anaesthesiol &

    Pain Med Bern Switzerland;

    Univ Bern Univ Hosp Bern Inselspital Dept Nephrol &

    Hypertens Bern Switzerland;

    Univ Bern Univ Hosp Bern Dept Diabet Endocrinol Nutr Med &

    Metab Inselspital Bern Switzerland;

    Univ Bern Univ Hosp Bern Dept Diabet Endocrinol Nutr Med &

    Metab Inselspital Bern Switzerland;

    Univ Bern Univ Hosp Bern Dept Diabet Endocrinol Nutr Med &

    Metab Inselspital Bern Switzerland;

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  • 正文语种 eng
  • 中图分类 内分泌腺疾病及代谢病;
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