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首页> 外文期刊>Diabetes care >Individual and Combined Associations of Modifiable Lifestyle and Metabolic Health Status With New-Onset Diabetes and Major Cardiovascular Events: The China Cardiometabolic Disease and Cancer Cohort (4C) Study
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Individual and Combined Associations of Modifiable Lifestyle and Metabolic Health Status With New-Onset Diabetes and Major Cardiovascular Events: The China Cardiometabolic Disease and Cancer Cohort (4C) Study

机译：可修饰的生活方式和新陈代谢健康状况的个体和综合协会，具有新的糖尿病和主要心血管事件：中国心肌植物疾病和癌症队列（4C）研究

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OBJECTIVE We aimed to determine the individual and combined associations of lifestyle and metabolic factors with new-onset diabetes and major cardiovascular events among a Chinese population aged >= 40 years. RESEARCH DESIGN AND METHODS Baseline lifestyle information, waist circumference, blood pressure, lipid profiles, and glycemic status were obtained in a nationwide, multicenter, prospective study of 170,240 participants. During the up to 5 years of follow-up, we detected 7,847 individuals with new-onset diabetes according to the American Diabetes Association 2010 criteria and 3,520 cardiovascular events, including cardiovascular death, myocardial infarction, stroke, and hospitalized or treated heart failure. RESULTS On the basis of 36.13% (population-attributable fraction [PAF]) risk attributed to metabolic risk components collectively, physical inactivity (8.59%), sedentary behavior (6.35%), and unhealthy diet (4.47%) moderately contributed to incident diabetes. Physical inactivity (13.34%), unhealthy diet (8.70%), and current smoking (3.38%) significantly contributed to the risk of major cardiovascular events, on the basis of 37.42% PAF attributed to a cluster of metabolic risk factors. Significant associations of lifestyle health status with diabetes and cardiovascular events were found across all metabolic health categories. Risks of new-onset diabetes and major cardiovascular events increased simultaneously according to the worsening of lifestyle and metabolic health status. CONCLUSIONS We showed robust effects of lifestyle status on new-onset diabetes and major cardiovascular events regardless of metabolic status and a graded increment of risk according to the combination of lifestyle and metabolic health, highlighting the importance of lifestyle modification regardless of the present metabolic status.
机译：目的我们旨在确定生活方式的个人和综合协会，新的糖尿病和中国人口中的新出现糖尿病和主要心血管事件的综合协会和= 40岁。研究设计和方法基准生活方式信息，腰围，血压，脂质曲线和血糖地位是在全国范围内，多中心的，前瞻性研究的170,240名参与者。在最多5年的随访期间，我们通过美国糖尿病协会2010年标准和3,520名心血管事件（包括心血管死亡，心肌梗死，中风和住院或治疗的心力衰竭）检测到新的糖尿病患者7,847个个体。结果基于36.13％（人口可归因级分[PAF]）的风险归因于代谢风险组分，身体不活跃（8.59％），久坐行为（6.35％），不健康的饮食（4.47％）适度促进入射糖尿病。体力活动（13.34％），不健康的饮食（8.70％），目前吸烟（3.38％）显著贡献主要心血管事件的风险，中37.42％PAF归因于代谢危险因素集群的基础上。所有代谢健康类别都发现了生活方式健康状况与糖尿病和心血管事件的重要组织。根据生活方式和代谢健康状况恶化，新出售糖尿病和主要心血管事件的风险同时增加。结论我们对新发病糖尿病和主要心血管事件的生活方式状态表现出强大的效果，无论是根据生活方式和代谢健康的结合，突出了性质和代谢健康的相结合，突出了生活方式修改的重要性，无论目前的代谢状况如何，都突出了生活方式修改的重要性。

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