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首页> 外文期刊>Developmental biology >Visceral endoderm and the primitive streak interact to build the fetal-placental interface of the mouse gastrula
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Visceral endoderm and the primitive streak interact to build the fetal-placental interface of the mouse gastrula

机译：内脏内胚层和原始条纹相互作用，以构建小鼠胃肠的胎儿界面

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Abstract Hypoblast/visceral endoderm assists in amniote nutrition, axial positioning and formation of the gut. Here, we provide evidence, currently limited to humans and non-human primates, that hypoblast is a purveyor of extraembryonic mesoderm in the mouse gastrula. Fate mapping a unique segment of axial extraembryonic visceral endoderm associated with the allantoic component of the primitive streak, and referred to as the “AX”, revealed that visceral endoderm supplies the placentae with extraembryonic mesoderm. Exfoliation of the AX was dependent upon contact with the primitive streak, which modulated Hedgehog signaling. Resolution of the AX’s epithelial-to-mesenchymal transition (EMT) by Hedgehog shaped the allantois into its characteristic projectile and individualized placental arterial vessels. A unique border cell separated the delaminating AX from the yolk sac blood islands which, situated beyond the limit of the streak, were not formed by an EMT. Over time, the AX became the hindgut lip, which contributed extensively to the posterior interface, including both embryonic and extraembryonic tissues. The AX, in turn, imparted antero-posterior (A-P) polarity on the primitive streak and promoted its elongation and differentiation into definitive endoderm. Results of heterotopic grafting supported mutually interactive functions of the AX and primitive streak, showing that together, they self-organized into a complete version of the fetal-placental interface, forming an elongated structure that exhibited A-P polarity and was composed of the allantois, an AX-derived rod-like axial extension reminiscent of the embryonic notochord, the placental arterial vasculature and visceral endoderm/hindgut. Highlights ? Mouse visceral endoderm and primitive streak form a posterior organizing center. ? The streak activates exfoliation of visceral endoderm into extraembryonic mesoderm. ? The epithelial-to-mesenchymal transition is resolved by Hedgehog. ? Visceral endoderm imparts antero-posterior polarity and potency on the primitive streak.
机译：抽象下胚层/中肠的脊椎动物的营养，轴向定位和形成内脏内胚层协助。在这里，我们提供的证据，目前仅限于人类和非人类的灵长类动物，即胚层在原肠胚鼠胚外中胚层的传播者。命运映射的一个独特的段轴向胚外内脏内胚层与原条的尿囊组件相关联，并且被称为“AX”，揭示了内脏内胚层用品与胚外中胚层的胎盘。对AX的剥离是取决于与原条，其中调制的Hedgehog信号接触。对AX的通过刺猬上皮 - 间充质转换（EMT）的分辨率形尿囊进入其特征弹丸和个性化的胎盘动脉血管。一个独特的边界小区从其中，位于超过条纹的限制，并没有由EMT形成卵黄囊血岛分离的剥离AX。随着时间的推移，对AX成为后肠唇，它广泛地有助于后部界面，包括胚胎和胚外组织。对AX，反过来，在原条施加的前 - 后（A-P）的极性和促进其伸长和分化成定形内胚层。异位移植的结果支持AX和原条的相互交互功能，显示出在一起时，它们自组织进入胎儿胎盘接口的完整版本，形成表现出AP极性并且由尿囊的细长结构， AX-衍生棒状胚胎脊索，胎盘动脉脉管系统和内脏内胚层/后肠的轴向延伸让人联想。强调 ？老鼠内脏内胚层和原条形成后组织中心。还是连胜激活内脏内胚层的剥落成胚外中胚层。还是上皮 - 间质转化由刺猬解决。还是内脏内胚层面授前 - 后极性和效力上的原条。

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