Ethanol and brain damage.

Harper C; Matsumoto I

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Ethanol and brain damage.

机译：乙醇和脑损伤。

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It is now well established that even uncomplicated alcoholics who have no specific neurological or hepatic problems show signs of regional brain damage and cognitive dysfunction. Improvements in neuroimaging technology, magnetic resonance imaging, magnetic resonance spectroscopy and positron emission tomography have contributed significantly, revealing alcoholic-specific changes in the CNS associated with neuropsychological abnormalities. Although greater efforts are needed, a human brain bank specifically targeting alcohol cases is now able to provide fresh and frozen tissue for alcohol researchers. These tissues can be used to test hypotheses developed using animal models and/or in vitro studies. The aim is to delineate mechanisms underlying alcohol-related brain damage in humans. The development of high-throughput, non-hypothesis-driven approaches using DNA microarrays and proteomics might also provide clues to this important problem.

机译：现已公认，即使没有复杂的酒精中毒者，也没有特定的神经系统或肝脏问题，也显示出区域性脑损伤和认知功能障碍的迹象。神经影像技术，磁共振成像，磁共振波谱和正电子发射断层扫描技术的改进已做出了重要贡献，揭示了CNS中酒精性特定变化与神经心理学异常有关。尽管需要付出更大的努力，但是专门针对酒精病例的人脑库现在能够为酒精研究人员提供新鲜和冷冻的组织。这些组织可用于测试使用动物模型和/或体外研究得出的假设。目的是描述人类与酒精相关的脑损伤的潜在机制。利用DNA微阵列和蛋白质组学开发高通量，非假设驱动的方法，也可能为这一重要问题提供线索。

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来源
《Current opinion in pharmacology》 |2005年第1期|共6页
作者
Harper C; Matsumoto I;
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正文语种 eng
中图分类药理学;
关键词
Brain damage; NOS; Alcohols; Alcohol measurement; proteomics; Problem drinker; 醇类;

机译：脑损伤;NOS;酒精;酒精测量;蛋白质组学;问题饮酒者;醇类;

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1. BHT blocks NF-kappaB activation and ethanol-induced brain damage. [J] . Crews F, Nixon K, Kim D, Alcoholism: Clinical and experimental research . 2006,第11期

机译：BHT阻断NF-κB活化和乙醇诱导的脑损伤。
2. Disulfiram is a direct and potent inhibitor of human O6-methylguanine-DNA methyltransferase (MGMT) in brain tumor cells and mouse brain and markedly increases the alkylating DNA damage. [J] . Ameya Paranjpe, Ruiwen Zhang, Francis Ali-Osman, Carcinogenesis . 2014,第3期

机译：双硫仑是脑肿瘤细胞和小鼠脑中人O6-甲基鸟嘌呤-DNA甲基转移酶（MGMT）的直接有效抑制剂，并显着增加了烷基化DNA的损伤。
3. Opposing effects of pigment epithelium-derived factor on breast cancer cell versus neuronal survival: implication for brain metastasis and metastasis-induced brain damage. [J] . Fitzgerald DP, Subramanian P, Deshpande M, Cancer research: The official organ of the American Association for Cancer Research, Inc . 2012,第1期

机译：色素上皮衍生因子对乳腺癌细胞与神经元存活的相反作用：对脑转移和转移引起的脑损伤的影响。
4. Binge consumption of ethanol during pregnancy leads to significant developmental delay of mouse embryonic brain [C] . Narendran Sudheendran, Shameena Bake, Rajesh C. Miranda, Optical methods in developmental biology II . 2014

机译：怀孕期间狂饮乙醇会导致小鼠胚胎脑的显着发育延迟
5. Brain growth spurt - prenatal ethanol exposure in the guinea pig: Effects on behaviour, cognition and hippocampal function, and comparison with chronic prenatal ethanol exposure. [D] . Byrnes, Laura Michelle. 2004

机译：脑生长突增-豚鼠产前乙醇暴露：对行为，认知和海马功能的影响，以及与慢性产前乙醇暴露的比较。
6. Genetic determinants of ethanol-induced liver damage. [O] . A. Monzoni, F. Masutti, G. Saccoccio, 2001

机译：乙醇引起的肝损伤的遗传决定因素。
7. Motor recovery after early brain damage. A case of brain plasticity. [O] . Sabatini U, Toni D, Pantano P, 1994

机译：早期脑损伤后运动恢复。一例大脑可塑性。
8. Regional Brain Acetylcholine Levels in Rats Acutely Treated with Ethanol or Rendered Ethanol-Dependent. [R] . Hunt, W. A., Dalton, T. K. 1976

机译：乙醇或乙醇依赖性乙醇急性加重大鼠局部脑乙酰胆碱水平的变化。

Ethanol and brain damage.

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