Myostatin, a negative regulator of muscle mass: implications for muscle degenerative diseases.

Tobin JF; Celeste AJ

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Myostatin, a negative regulator of muscle mass: implications for muscle degenerative diseases.

机译：肌生长抑制素，肌肉质量的负调节剂：对肌肉退行性疾病的影响。

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Myostatin is a secreted protein that negatively regulates skeletal muscle mass determining both muscle fiber number and size. The myostatin pathway is conserved and regulates muscle mass in a number of animal species ranging from fish to humans. Inhibition of myostatin using a variety of therapeutic approaches can increase muscle mass in a number of animal models of human disease, including muscular dystrophy.

机译：肌生长抑制素是一种分泌蛋白，可负调节骨骼肌质量，从而决定肌肉纤维的数量和大小。肌肉生长抑制素途径是保守的，并调节从鱼到人的许多动物物种的肌肉质量。使用多种治疗方法抑制肌生长抑制素可以在包括肌肉营养不良在内的许多人类疾病动物模型中增加肌肉质量。

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《Current opinion in pharmacology》 |2005年第3期|共5页
作者
Tobin JF; Celeste AJ;
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正文语种 eng
中图分类药理学;
关键词
Muscles; Mass; NOS; myostatin; SIZES; Models; Animal; 肌;

机译：肌肉;质量;NOS;肌生长抑制素;大小;模型;动物;肌;

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1. Myostatin, a negative regulator of muscle mass: implications for muscle degenerative diseases. [J] . Tobin JF, Celeste AJ Current opinion in pharmacology . 2005,第3期

机译：肌生长抑制素，肌肉质量的负调节剂：对肌肉退行性疾病的影响。
2. Improved muscle healing after contusion injury by the inhibitory effect of suramin on myostatin, a negative regulator of muscle growth. [J] . Nozaki M, Li Y, Zhu J American Journal of Sports Medicine . 2008,第12期

机译：苏拉明对肌生长抑制素（肌肉生长的负调节剂）的抑制作用，改善了挫伤后肌肉的愈合。
3. Myostatin as a mediator of sarcopenia versus homeostatic regulator of muscle mass: insights using a new mass spectrometry-based assay [J] . H. Robert Bergen, Joshua N. Farr, Patrick M. Vanderboom, Skeletal Muscle . 2015,第1期

机译：肌生长抑制素作为肌肉减少症与肌肉质量稳态调节剂的介体：使用基于质谱的新检测方法的见解
4. Determination of deltamethrin in rat muscle and liver using gas chromatography (GC) negative chemical ionization mass spectrometry. [C] . Darren Gullick, Andrew Popovici, Holly Young, ASMS Conference on Mass Spectrometry and Allied Topics . 2014

机译：用气相色谱法测定大鼠肌肉和肝脏中溴氰菊酯的测定负化学电离质谱。
5. Myostatin as a negative regulator of skeletal muscle growth: Identification of upstream effectors, signaling modulators and gene targets [D] . Muthuri, Stella Kagwiria 2007

机译：肌生长抑制素作为骨骼肌生长的负调节剂：上游效应子，信号调节剂和基因靶标的鉴定
6. Myostatin as a mediator of sarcopenia versus homeostatic regulator of muscle mass: insights using a new mass spectrometry-based assay [O] . H. Robert Bergen III, Joshua N. Farr, Patrick M. Vanderboom, 2015

机译：肌生成抑制素作为肌肉减少症与肌肉质量稳态调节剂的介体：使用基于质谱的新检测方法的见解
7. Increased Myostatin as a Negative Regulator of Muscle Regeneration Potential in Sarcopenic COPD Patients: Clinical Implications [O] . E. Barreiro, A. Sancho-Muñoz, M. Guitart, 2020

机译：肌球素增加作为肌肉再生潜力的阴性调节因子：临床意义
8. Modulation of Stem Cell Differentiation and Myostatin as an Approach to Counteract Fibrosis in Muscle Dystrophy and Regeneration After Injury. Addendum. [R] . Gonzalez-Cadavid, N. F. 2012

机译：调节干细胞分化和肌肉生长抑制素作为抵抗损伤后肌肉萎缩和再生纤维化的途径。附录。

Myostatin, a negative regulator of muscle mass: implications for muscle degenerative diseases.

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