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首页> 外文期刊>Current opinion in pharmacology >Psychostimulants and monoamine transporters: upsetting the balance.
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Psychostimulants and monoamine transporters: upsetting the balance.

机译：精神兴奋剂和单胺转运蛋白：破坏平衡。

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摘要

Monoamine transporters were originally associated simply with the termination of synaptic monoamine function. In addition to amine reuptake, however, the transporters can act as ion channels that affect exocytotic neurotransmitter release and can operate in reverse mode, mediating non-exocytotic amine release. Activity at the plasma membrane is controlled by trafficking, which is modulated by interaction with both substrates and inhibitors and by cytosolic kinases and phosphatases. Monoamine transporters also constitute the principal sites of action of many psychoactive drugs, including amphetamines and cocaine, as well as therapeutic drugs for the treatment of depression, addiction and attention deficit hyperactivity disorder, each modifying the balance of presynaptic neurotransmitter function.
机译：单胺转运蛋白最初只是与突触单胺功能的终止有关。然而，除了胺的再摄取外，转运蛋白还可以作为影响胞外神经递质释放的离子通道，并且可以逆向运行，介导非胞外胺的释放。通过转运来控制质膜上的活性，转运通过与底物和抑制剂的相互作用以及胞质激酶和磷酸酶来调节。单胺转运蛋白还构成许多精神药物的主要作用部位，包括苯丙胺和可卡因，以及用于治疗抑郁症，成瘾和注意缺陷多动障碍的治疗药物，每种药物都会改变突触前神经递质功能的平衡。

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