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首页> 外文期刊>Journal of Agricultural and Food Chemistry >Polyoxygenated Cyclohexenoids with Promising alpha-Glycosidase Inhibitory Activity Produced by Phomopsis sp YE3250, an Endophytic Fungus Derived from Paeonia delavayi
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Polyoxygenated Cyclohexenoids with Promising alpha-Glycosidase Inhibitory Activity Produced by Phomopsis sp YE3250, an Endophytic Fungus Derived from Paeonia delavayi

机译：具有由PhoMopsis SP YE3250产生的有前途的α-糖苷酶抑制活性的聚氧化环己烯醇，衍生自Paeonia Delavayi的内生真菌

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摘要

Seven new polyoxygenated cyclohexenoids, namely, phomopoxides A-G (1-7), were isolated from the fermentation broth extract of an endophytic fungal strain Phomopsis sp. YE3250 from the medicinal plant Paeonia delavayi Franch. The structures of these compounds were established by spectroscopic interpretation. The absolute configurations of compounds 1 and 4 were confirmed by X-ray crystallographic analysis and chemical derivative approach. All isolated compounds showed weak cytotoxic activities toward three human tumor cell lines (Hela, MCF-7, and NCI-H460) and weak antifungal activities against five pathogenic fungi (Candida albicans, Aspergillus niger, Pyricularia oryzae, Fusarium avenaceum, and Hormodendrum compactum). In addition, compounds 1-7 showed a promising a-glycosidase inhibitory activity with IC50 values of 1.47, 1.55, 1.83, 2.76, 2.88, 3.16, and 2.94 mM, respectively, as compared with a positive control of acarbose (IC50 = 1.22 mM).
机译：七种新的聚氧化环己烯醇，即Phomopoxides A-G（1-7），从内生真菌菌株Phomopsis Sp的发酵肉汤提取物中分离出来。 YE3250来自药用植物Paeonia Delavayi Franch。 通过光谱解释建立这些化合物的结构。 通过X射线晶体分析和化学衍生物方法证实了化合物1和4的绝对构型。 所有分离的化合物均显示出三种人肿瘤细胞系（Hela，MCF-7和NCI-H460）的细胞毒性活动弱毒性活动，以及针对五种致病性真菌的弱抗真菌活动（念珠菌，曲霉尼日尔，肥华菊属植物，毛囊植物和Hormodendrum Compactum） 。 此外，与氨基糖的阳性对照相比，化合物1-7表现出具有1.47,1.55,1.83,2.76,2.88,3.16和2.94mm的IC 50值的促进α-糖苷酶抑制活性。（IC50 = 1.22 mm） ）。

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  • 作者

    Huang Rong; Jiang Bo-Guang; Li Xiao-Nian; Wang Ya-Ting; Liu Si-Si; Zheng Kai-Xuan; He Jian; Wu Shao-Hua;

  • 作者单位

    Yunnan Univ Sch Chem Sci &

    Technol Kunming 650091 Yunnan Peoples R China;

    Yunnan Univ Yunnan Inst Microbiol Key Lab Microbial Resources Minist Educ Kunming 650091 Yunnan Peoples R China;

    Chinese Acad Sci Kunming Inst Bot State Key Lab Phytochem &

    Plant Resources West Ch Kunming 650201 Yunnan Peoples R China;

    Yunnan Univ Yunnan Inst Microbiol Key Lab Microbial Resources Minist Educ Kunming 650091 Yunnan Peoples R China;

    Yunnan Univ Yunnan Inst Microbiol Key Lab Microbial Resources Minist Educ Kunming 650091 Yunnan Peoples R China;

    Yunnan Univ Yunnan Inst Microbiol Key Lab Microbial Resources Minist Educ Kunming 650091 Yunnan Peoples R China;

    Southern Med Univ Sch Pharmaceut Sci Grp Peptides &

    Nat Prod Res Guangzhou 510515 Guangdong Peoples R China;

    Yunnan Univ Yunnan Inst Microbiol Key Lab Microbial Resources Minist Educ Kunming 650091 Yunnan Peoples R China;

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 营养卫生、食品卫生;农业科学;
  • 关键词

    Phomopsis; Paeonia delavayi; polyoxygenated cyclohexenoids; alpha-glucosidase inhibitor;

    机译：Phomopsis;Paeonia Delavayi;聚氧化环己烯酸;α-葡糖苷酶抑制剂;

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