...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Journal of Agricultural and Food Chemistry >The Peptide AmPep1 Derived from Amaranth Recognizes the Replication Hairpin of TYLCV Disturbing Its Replication Process in Host Plants
【24h】

The Peptide AmPep1 Derived from Amaranth Recognizes the Replication Hairpin of TYLCV Disturbing Its Replication Process in Host Plants

机译：来自苋菜的肽AMPep1认识到Tylcv的复制发夹，扰乱宿主植物中的复制过程

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Antiviral compounds targeting viral replicative processes have been studied as an alternative for the control of begomoviruses. Previously, we have reported that the peptide AmPep1 has strong affinity binding to the replication origin sequence of tomato yellow leaf curl virus (TYLCV). In this study, we describe the mechanism of action of this peptide as a novel alternative for control of plant-infecting DNA viruses. When AmPep1 was applied exogenously to tomato and Nicotiana benthamiana plants infected with TYLCV, a decrease in the synthesis of the two viral DNA strands (CS and VS) was observed, with a consequent delay in the development of disease progress in treated plants. The chemical mechanism of action of AmPep1 was deduced using Raman spectroscopy and molecular modeling showing the formation of chemical interactions such as H bonds and electrostatic interactions and the formation of pi-pi interactions between both biomolecules contributing to tampering with the viral replication.
机译：已经研究了靶向病毒复制过程的抗病毒化合物作为对前豚病毒控制的替代方案。以前，我们报道了肽AMPep1与番茄黄叶卷曲病毒（Tylcv）的复制源序列具有强烈的亲和力结合。在这项研究中，我们描述了这种肽的作用机制作为一种用于控制植物感染DNA病毒的新型替代品。当AMPEP1对番茄和尼古利亚纳·尼育植物感染TylCV的植物，观察到两种病毒DNA链（Cs和Vs）的合成减少，因此治疗植物中疾病进展的发展延迟。使用拉曼光谱和分子建模推导出AMPep1的化学作用机制和分子建模，显示化学相互作用，例如H键和静电相互作用，以及两种生物分子之间的PI-PI相互作用，有助于篡改病毒复制。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号