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首页> 外文期刊>Journal of Agricultural and Food Chemistry >An Eco- and User-Friendly Herbicide
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An Eco- and User-Friendly Herbicide

机译：生态和用户友好的除草剂

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The increasing use of pesticides in agriculture and gardening has caused severe deterioration to both the ecosystem and the health of users (human beings), so there is an urgent need for eco- and user-friendly pesticides. Among a variety of herbicides, paraquat (PQ), frequently used as an effective herbicidal agent worldwide, is well-known for its serious toxicity that has killed, and harmed, thousands of people and countless wildlife such as fish. Herein, we present a facile supramolecular formulation of PQ@cucurbit[7]uril (PQ@CB[7]), prepared by simply mixing PQ with equivalent (molar) CB[7] in water. With addition of CB[7], PQ's cellular uptake was dramatically inhibited. The reactive oxygen species (ROS) generation and the associated apoptosis otherwise induced by PQ in cellular models were both reduced, resulting in increased cellular viability. In a wildtype zebrafish model that is a typical fragile wildlife species in the ecosystem, the supramolecular formulation exhibited significantly reduced hepatotoxicity and increased survival rate, in comparison with those of the fish exposed to free PQ. In a mouse model that is clinically relevant to human being, the administration of PQ@CB[7] significantly alleviated major organ injuries and unusual hematological parameters that were otherwise induced by free PQ, resulting in a significantly increased survival rate. Meanwhile, this formulation maintained effective herbicidal activity that was equivalent to that of free PQ. Taken together, this facile supramolecular PQ formulation is providing not only an extremely rare example of an eco- and user-friendly herbicide that has been desired for decades but also a practical solution for green agriculture.
机译：越来越多地利用农药在农业和园艺中对生态系统和用户的健康（人类）产生严重恶化，因此迫切需要生态和用户友好的杀虫剂。在各种除草剂中，经常用作全世界有效的除草剂的百草枯（PQ），众所周知，由于其严重毒性，并受到了杀害，伤害了成千上万的人和无数野生动物如鱼。在此，我们通过简单地将PQ与水中的PQ与当量（摩尔）CB [7]混合来介绍PQ-uCurburit [7] URIL（PQ-CB [7]）的容易的超分子制剂。随着CB [7]，PQ的细胞吸收显着抑制。通过PQ中的PQ诱导的反应性氧物质（ROS）产生和相关的细胞凋亡均降低，导致细胞活力增加。在野生型斑马鱼模型中，是一种典型的脆弱野生动物种类在生态系统中，与暴露于自由PQ的鱼类相比，超分子制剂显着降低了肝毒性和增加的存活率。在与人类临床相关的小鼠模型中，PQ @ CB [7]的给药显着缓解了通过游离PQ否则诱导的主要器官损伤和不寻常的血液学参数，导致生存率显着增加。同时，这种配方保持了有效的除草活性，其等同于游离PQ的活性。在一起，这种容易的超分子PQ配方是不仅提供了几十年所需的生态和用户友好的除草剂的极少数，而且提供了绿色农业的实用解决方案。

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