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首页> 外文期刊>Journal of Agricultural and Food Chemistry >gamma-Mangostin Ameliorates Free Fatty Acid-Induced Lipid Accumulation via the SIRT1/LKB1/AMPK Pathway in HepG2 and L02 Cells
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gamma-Mangostin Ameliorates Free Fatty Acid-Induced Lipid Accumulation via the SIRT1/LKB1/AMPK Pathway in HepG2 and L02 Cells

机译：Gamma-mangostin通过HepG2和L02细胞的SIRT1 / LKB1 / AMPK途径改善游离脂肪酸诱导的脂质积累

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摘要

Lipid accumulation is a typical characteristic of nonalcoholic fatty liver disease (NAFLD). The inhibition of lipid accumulation is regarded as a potential treatment for NAFLD. In this study, we investigated the effects of gamma-mangostin or alpha-mangostin on lipid accumulation in a cell model. Analysis of the inhibitory effects of gamma-mangostin on lipid accumulation revealed that it downregulated NAFLD-related biochemical parameters and stimulated the SIRT1/LKB1/AMPK pathway. Consequently, it suppressed lipid synthesis and enhanced fatty acid oxidation. Moreover, we demonstrated that the blockage of AMP-activated protein kinase (AMPK) by the pharmacological inhibitor Compound C abrogated the promoting effect of AMPK. Similar results were also observed for alpha-mangostin. The effects of alpha-mangostin on lipid accumulation were inferior to those of gamma-mangostin. The differences in CPT1A activity might be originated from their different chemical structures. Our results suggested that gamma-mangostin and alpha-mangostin can be exploited as potential candidates for NAFLD treatment.
机译：脂质蓄积是酒精性脂肪肝疾病（NAFLD）的典型特征。脂质积累的抑制视为NAFLD的潜在治疗。在这项研究中，我们调查了在细胞模型脂质蓄积伽玛倒捻子素或α-倒捻子素的影响。对脂质积累伽玛倒捻子素的抑制效应分析表明，下调NAFLD相关的生化指标和刺激SIRT1 / LKB1 / AMPK通道。因此，抑制了脂质合成和增强的脂肪酸氧化。此外，我们证明，AMP活化的蛋白激酶的（AMPK）由药理抑制剂化合物的堵塞Ç废止AMPK的促进效果。类似的结果也为阿尔法倒捻子素观察。阿尔法倒捻子素对脂肪积累的效应不亚于那些伽玛倒捻子素。在CPT1A活动的差异可能源于其不同的化学结构。我们的研究结果表明，伽玛倒捻子素和α-倒捻子，可被利用作为NAFLD治疗的潜在候选人。

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  • 来源
  • 作者

    Gu Liang; Cai Nan; Lyu Yansi; Yao Lijun; Wang Fei; Xu Hong; Hu Zhangli; Li Hui; Xu Xu;

  • 作者单位

    Shenzhen Univ Shenzhen Key Lab Marine Bioresource &

    Ecoenvironm Guangdong Prov Key Lab Plant Epigenet Coll Life S Coll Optoelect Engn Minist Educ &

    Guangdong Prov Shenzhen 518060 Guangdong Peoples R China;

    Shenzhen Univ Shenzhen Key Lab Marine Bioresource &

    Ecoenvironm Guangdong Prov Key Lab Plant Epigenet Coll Life S Coll Optoelect Engn Minist Educ &

    Guangdong Prov Shenzhen 518060 Guangdong Peoples R China;

    Shenzhen Univ Gen Hosp Dept Dermatol Shenzhen 518055 Guangdong Peoples R China;

    Shenzhen Univ Shenzhen Key Lab Marine Bioresource &

    Ecoenvironm Guangdong Prov Key Lab Plant Epigenet Coll Life S Coll Optoelect Engn Minist Educ &

    Guangdong Prov Shenzhen 518060 Guangdong Peoples R China;

    Shenzhen Univ Gen Hosp Dept Spine Surg Shenzhen 518055 Guangdong Peoples R China;

    Shenzhen Univ Shenzhen Key Lab Marine Bioresource &

    Ecoenvironm Guangdong Prov Key Lab Plant Epigenet Coll Life S Coll Optoelect Engn Minist Educ &

    Guangdong Prov Shenzhen 518060 Guangdong Peoples R China;

    Shenzhen Univ Shenzhen Key Lab Marine Bioresource &

    Ecoenvironm Guangdong Prov Key Lab Plant Epigenet Coll Life S Coll Optoelect Engn Minist Educ &

    Guangdong Prov Shenzhen 518060 Guangdong Peoples R China;

    Shenzhen Univ Shenzhen Key Lab Marine Bioresource &

    Ecoenvironm Guangdong Prov Key Lab Plant Epigenet Coll Life S Coll Optoelect Engn Minist Educ &

    Guangdong Prov Shenzhen 518060 Guangdong Peoples R China;

    Shenzhen Univ Shenzhen Key Lab Marine Bioresource &

    Ecoenvironm Guangdong Prov Key Lab Plant Epigenet Coll Life S Coll Optoelect Engn Minist Educ &

    Guangdong Prov Shenzhen 518060 Guangdong Peoples R China;

  • 收录信息
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 营养卫生、食品卫生;农业科学;
  • 关键词

    the AMPK pathway; Compound C; alpha-mangostin; gamma-mangostin; nonalcoholic fatty liver disease (NAFLD);

    机译：AMPK途径;化合物C;α-颅孕蛋白;γ-植物蛋白;非酒精脂肪肝病（NAFLD）;

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