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首页> 外文期刊>Journal of Agricultural and Food Chemistry >Nobiletin Triggers Reactive Oxygen Species-Mediated Pyroptosis through Regulating Autophagy in Ovarian Cancer Cells
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Nobiletin Triggers Reactive Oxygen Species-Mediated Pyroptosis through Regulating Autophagy in Ovarian Cancer Cells

机译：Nobiletin通过调节卵巢癌细胞中的自噬触发反应性氧物种介导的γ唑

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摘要

Ovarian cancer is one of the most serious female malignancies worldwide. Despite intensive efforts being made to overcome ovarian cancer, there still remain limited optional treatments for this disease. Nobiletin, a prospective food-derived phytochemical extracted from citrus fruits, has recently been reported to suppress ovarian cancer cells, but the role of pyroptosis in ovarian carcinoma with nobiletin still remains unknown. In this study, we aim to explore the effect of nobiletin on ovarian carcinoma and further expound the underlying mechanisms of nobiletin-induced ovarian cancer cell death. Our results showed that nobiletin could significantly inhibit cell proliferation, induce DNA damage, and also lead to apoptosis by increasing the cleaved poly (ADP-ribose) polymerase (PARP) level of human ovarian cancer cells (HOCCs) in a dose-dependent manner. Moreover, we revealed that nobiletin decreased mitochondrial membrane potential and induced reactive oxygen species (ROS) generation and autophagy of HOCCs, contributing to gasdermin D-/gasdermin E-mediated pyroptosis. Taken together, nobiletin as a functional food ingredient represents a promising new anti-ovarian cancer candidate that could induce apoptosis and trigger ROS-mediated pyroptosis through regulating autophagy in ovarian cancer cells.
机译：卵巢癌是全球最严重的女性恶性肿瘤之一。尽管正在克服卵巢癌的密切努力，但仍然存在有限的可选治疗方法。据报道，Nobiletin是从柑橘类水果中提取的预期食品衍生的植物化学物质，以抑制卵巢癌细胞，但糊抑菌在卵巢癌与Nobiletin的作用仍然未知。在这项研究中，我们的目标是探讨NeBiletin对卵巢癌的影响，进一步阐述了卵巢蛋白癌细胞死亡的潜在机制。我们的研究结果表明，Nobiletin可以显着抑制细胞增殖，诱导DNA损伤，并通过以剂量依赖性方式增加人卵巢癌细胞（HOCC）的切割聚（ADP-核糖）聚合酶（PARP）水平来导致细胞凋亡。此外，我们透露，Nobiletin降低了线粒体膜潜力和诱导的HOCC的生成和自噬的诱导的Hoccs，促进了燃气蛋白D- /汽笛E介导的辐射瘤病。携带在一起，Nobiletin作为功能性食品成分代表了有希望的新的抗卵巢癌候选者，可以通过调节卵巢癌细胞中的自噬诱导细胞凋亡和触发ROS介导的糊菌。

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