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首页> 外文期刊>Journal of Agricultural and Food Chemistry >Anti-inflammatory Principles from Sarcandra glabra
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Anti-inflammatory Principles from Sarcandra glabra

机译：来自 Sarcandra Glabra的抗炎原理

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摘要

Sarcandra glabra (Thunb.) Nakai (Chloranthaceae) is a medicinal plant used as herbal tea or food supplement to promote human health. We isolated 14 phenolic compounds from the n-butanol fraction of S.?glabra and investigated their anti-inflammatory potential using lipopolysaccharide (LPS)-activated RAW264.7 macrophages. We demonstrated that methyl isorinate, a previously uncharacterized compound in S.?glabra, is able to suppress NF-κB activation and reduce the expression of iNOS and COX-2 as well as the phosphorylation of IκB in LPS-treated RAW264.7 cells. In addition, the production of two inflammatory cytokines (IL-6 and TNF-α), as well as release of reactive oxygen species, in the LPS-stimulated macrophages was also inhibited by this compound. Furthermore, the structure–activity relationships of all of the isolated phenolic compounds present were analyzed. Overall, this study revealed several anti-inflammatory compounds that were present in S.?glabra, and the results suggest that these diverse phenolic compounds are associated with the anti-inflammatory effects of S.?glabra.]]>
机译：<！[cdata [ src ='http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/jafcau/2017/jafcau.2017.65.issue-31/acs.jafc.6b05125/ 20170803 / Images / Medium / JF-2016-05125J_0008.gif“> Sarcandra Glabra （Thunb。）Nakai（醋酸）是一种用作凉茶或食品补充剂的药用植物，以促进人类健康。我们将14个酚类化合物分离出来的14个酚类化合物 - 丁醇级数的 S.?Glabra，并使用脂多糖（LPS） - 活化的Raw264.7巨噬细胞研究其抗炎潜力。我们证明了甲基甲基甲基，在 S.？Gla​​bra中，以前的无特征化合物，能够抑制NF-κB活化并降低InOS和COX-2的表达以及LPS中IκB的磷酸化合物-Treated Raw264.7细胞。此外，通过该化合物还抑制了在LPS刺激的巨噬细胞中产生两种炎症细胞因子（IL-6和TNF-α）的产生，以及反应性氧物质的释放。此外，分析了所有分离的酚类化合物的结构 - 活性关系。总的来说，该研究揭示了几种存在于β/ i>中的抗炎化合物，结果表明这些不同的酚类化合物与 s的抗炎作用有关。 glabra 。]>

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