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首页> 外文期刊>Journal of Agricultural and Food Chemistry >Asiaticoside Mitigates the Allergic Inflammation by Abrogating the Degranulation of Mast Cells
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Asiaticoside Mitigates the Allergic Inflammation by Abrogating the Degranulation of Mast Cells

机译：AsiaticoSide通过消除肥大细胞的脱血来减轻过敏性炎症

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摘要

The effects of asiaticoside (AS) on allergic responses mediated by mast cells were investigated. AS showed no obvious cytotoxicity on RPMCs (rat peritoneal mast cells). AS reduced the intracellular calcium in RPMCs and deprived the histamine release and degranulation. AS also decreased the generation of antigen-induced tumor necrosis factor alpha, interleukin (IL)-4, IL-8, and IL-1 beta in RBL-2H3 cells sensitized by IgE. The suppression of AS on pro-inflammatory cytokines was related with the activation of the intracellular FceRI and the inhibition of the nuclear factor-kappa B signaling pathway. In addition, AS disabled the phosphorylation of antigen-induced Syk, Lyn, Gab2, and PLC gamma 1, thus suppressing the downstream Akt phosphorylation and MAPKs pathways. It also increased HO-1 and Nrf2 expression time dependently. In summary, we demonstrate that AS suppresses the allergic inflammation mediated by mast cells and this effect might be mediated by Fc epsilon RI-dependent signaling pathways.
机译：研究了Asiaticoside（AS）对由MAST细胞介导的过敏反应的影响。如对RPMCs（大鼠腹膜肥大细胞）没有明显的细胞毒性。减少了RPMC中的细胞内钙，并剥夺了组胺释放和脱粒。也降低了通过IgE致敏的RBL-2H3细胞中的抗原诱导的肿瘤坏死因子α，白细胞介素（IL）-4，IL-8和IL-1β和IL-1β。抑制促炎细胞因子与细胞内Fceri的激活有关，抑制核因子-Kappa发信号通路。另外，作为禁用抗原诱导的Syk，Lyn，GAB2和PLCγ1的磷酸化，从而抑制下游AKT磷酸化和MAPK途径。它还依赖于HO-1和NRF2表达。总之，我们证明，抑制了肥大细胞介导的过敏性炎症，并且这种效果可能由依赖于Fc epsilon Ri依赖性信号通路介导。

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