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Fabrication of microfluidic chips using controlled dissolution of 3D printed scaffolds

机译:使用3D印刷支架的控制溶解制备微流体芯片

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摘要

Microfluidic chips are commonly fabricated using soft lithography, which often requires a clean room and micropatterning equipment. Recently, microfluidic chips are increasingly fabricated using 3D printing, but this technology is still limited in smallest channel printability, transparency, supports residue, and biocompatibility. In this work, a simple, fast, and inexpensive step is introduced to fabricate polydimethylsiloxane (PDMS) microfluidic chips using enhanced internal scaffold removal (eISR). It is found that final channel dimension decreases by 0.22 +/- 0.02 mu m/revolution with a 7% error using eISR. Surface topology is inspected after dissolution using scanning electron microscopy. A T-junction device, bifurcation channels, and curved channels are fabricated to demonstrate the usability of eISR in multiple applications. Compared to previous methods, eISR provides acrylonitrile-butadiene-styrene dissolution before PDMS casting to achieve thinner and smoother channels produced using a commercial 3D printer.
机译:微流体芯片通常使用柔软的光刻制造,这些芯片通常需要洁净室和微图案设备。最近,使用3D印刷越来越多地制造微流体芯片,但这种技术仍然限制在最小的通道可印刷性,透明度,支持残留物和生物相容性。在这项工作中,引入简单,快速,廉价的步骤以使用增强的内部支架去除(EISR)制造聚二甲基硅氧烷(PDMS)微流体芯片。发现最终通道尺寸减少0.22 +/- 0.02 mu m /旋转,使用EISR误差为7%。使用扫描电子显微镜溶解后检查表面拓扑。制造了T型连接装置,分叉通道和弯曲通道,以展示EISR在多种应用中的可用性。与先前的方法相比,EISR在PDMS铸造之前提供丙烯腈 - 丁二烯 - 苯乙烯溶解,以实现使用商业3D打印机生产的更薄和更平滑的通道。

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