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首页> 外文期刊>Journal of Applied Polymer Science >Blending chitosan-g-poly(caprolactone) with poly(caprolactone) by electrospinning to produce functional fiber mats for tissue engineering applications
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Blending chitosan-g-poly(caprolactone) with poly(caprolactone) by electrospinning to produce functional fiber mats for tissue engineering applications

机译：通过静电纺丝将Chitosan-G-Poly（己内酯）用聚（己内酯）产生用于组织工程应用的功能纤维垫

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摘要

Use of electrospun fiber mats for tissue engineering applications has become increasingly prominent. One of the most important polymers in research, poly(epsilon-caprolactone) (PCL), however, lacks biological performance, easy access to modifications and cellular recognition sites. To improve these properties and to enable further modifications, PCL was blended with chitosan grafted with PCL (CS-g-PCL) and subsequently processed via electrospinning. In this way, chitosan was enriched at the fiber's surface presenting cationic amino groups. The fiber mats were analyzed by various techniques such as scanning electron microscopy (SEM), confocal laser scanning microscopy (CLSM), and X-ray photoelectron spectroscopy (XPS). Furthermore, analyzing thermal properties and crystallinity, showed that an increased content of CS-g-PCL in blend composition leads to a higher overall crystallinity in produced fiber mats. Blending CS-g-PCL into PCL significantly increased initial cellular attachment and proliferation as well as cell vitality, while maintaining adequate mechanical properties, fiber diameter, and interstitial volume. As proof of principle for easy access to further modification, fluorescently labeled alginate (Alg-FA) was attached to the fiber's surface and verified by CLSM. Hence, blending CS-g-PCL with PCL can overcome an inherent weakness of PCL and create bioactive implants for tissue engineering applications. (c) 2019 The Authors. Journal of Applied Polymer Science published by Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2019, 137, 48650.
机译：用于组织工程应用的电纺纤维垫的使用变得越来越突出。然而，研究中最重要的聚合物之一，然而，缺乏生物学性能，容易获得修饰和蜂窝识别位点。为了改善这些性质并实现进一步的修饰，将PCL与壳聚糖与PCl（CS-G-PCL）接枝并随后通过电刺刺激加工。以这种方式，壳聚糖富含纤维表面呈现阳离子氨基。通过各种技术进行分析纤维垫，例如扫描电子显微镜（SEM），共聚焦激光扫描显微镜（CLSM）和X射线光电子谱（XPS）。此外，分析热性质和结晶度，表明共混物组合物中的Cs-G-PCL含量增加导致产生的纤维垫中的更高的整体结晶度。将Cs-G-PCL与PCL混合显着增加了初始细胞附着和增殖以及细胞活力，同时保持足够的机械性能，纤维直径和间质量。作为方便进一步改性的原理的证据，荧光标记的藻酸盐（ALG-FA）连接到纤维表面并由CLSM验证。因此，将CS-G-PCL与PCL混合可以克服PCL的固有弱性，并为组织工程应用产生生物活性植入物。 （c）2019年作者。中国威廉公司J.Phop的应用聚合物科学学报。聚合物。 SCI。 2019,137,48650。

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