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首页> 外文期刊>Journal of Applied Polymer Science >A novel drug loading and release from a thermoresponsive hydrogel formed in situ emulsion polymerization
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A novel drug loading and release from a thermoresponsive hydrogel formed in situ emulsion polymerization

机译：从原位乳液聚合形成的热响应水凝胶中的一种新型药物载荷和释放

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摘要

A facile thermoresponsive injectable hydrogel is prepared from stearyl methacrylate (SMA) and N-isopropyl acrylamide (NIPAM) copolymers via reversible addition-fragmentation chain-transfer (RAFT) emulsion polymerization method. By regulating the content of the oil phase, emulsions with divergent properties are obtained. The yield stress and the viscosity results of the emulsions increase evidently as the initial content of the oil phase increase from 10 to 40%. The microstructures of 10% oil content sample (SN10) is seen as a dispersed particle whereas 20, 30, and 40% oil content samples (SN20, SN30, and SN40) appear as aggregated particles in a dilute solution that shows the microscopical phase transitions of the emulsions. Increasing the temperature from 15 to 45 degrees C, phase separation takes place, the emulsions contract to squeeze the water. A sharp decrease in particle size is noticed when the temperature increase from 30 to 35 degrees C. In this point, hydrophilic drug procaine is loaded and release experiments are conducted using thermoresponsive injectable hydrogel. The drug loading and release results are evaluated using the Weibull distribution model and the Fick's law of diffusion that precisely works out. A thermoresponsive injectable hydrogel offers an efficient, cost-effective, and scalable approach towards controlled release of drugs. (C) 2019 Wiley Periodicals, Inc.
机译：通过可逆添加 - 碎片链转移（RAFT）乳液聚合方法，由硬脂甲酸甲基丙烯酸酯（SMA）和N-异丙基丙烯酰胺（NIPAM）共聚物制备容易热反应性可注射水凝胶。通过调节油相的含量，获得具有发散性质的乳液。乳液的屈服应力和粘度结果随着油相的初始含量从10％增加到40％而增加。 10％油含量样品（SN10）的微观结构被视为分散颗粒，而20,30和40％的油含量样品（SN20，SN30和SN40）在稀释溶液中出现聚集颗粒，其显示显微阶段转变乳液。将温度从15至45摄氏度增加，相分离发生，乳液合同挤压水。当温度从30至35℃的温度增加时，注意到粒度的急剧下降。在此时，加载亲水药物促进药物，并使用热响应注入水凝胶进行释放实验。使用Weibull分布模型和Fick的扩散定律评估药物载荷和释放结果，精确地解决。热响应的注射水凝胶提供了一种有效，经济效益和可扩展的药物控制释放方法。 （c）2019 Wiley期刊，Inc。

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