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首页> 外文期刊>Journal of Applied Polymer Science >Stretchable poly(glycerol-sebacate)/beta-tricalcium phosphate composites with shape recovery feature by extrusion
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Stretchable poly(glycerol-sebacate)/beta-tricalcium phosphate composites with shape recovery feature by extrusion

机译：拉伸聚（甘油 - 癸二酸酯）/β-三钙磷酸钙复合材料，具有挤出形状回收特征

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There has been a great interest in research towards elastomers and their composites with an attempt to obtain the desired biological and mechanical response to scaffold materials in bone tissue engineering. Composites made of ceramic-thermoplastic mixtures have been shown success to deliver the inorganic component while fail to provide replacement of an elastic protein, that is, collagen, of the target bone tissue. Thus, in order to match up with the inherent elasticity of the native tissue, it is proposed an alternative to well-known thermoplastic-containing matrices by using a poly(glycerol-sebacate) (PGS)-beta-tricalcium phosphate elastomeric composite to offer flexibility and mechanical integrity. This study reports for the first time a successful extrusion of PGS containing biodegradable composites with shape-memory feature. The resulting structures are physically and chemically characterized. In vitro cell culture performance of the obtained materials is investigated by using an MC3T3-E1 mouse preosteoblast cell line. The materials obtained in this study can be shaped into the desired size and various forms via temperature stimuli. Resulting materials have been proposed for craniofacial tissue engineering as a bone filler in which surgeons need to shape biomaterials during the surgical procedure due to the complex geometry of the bones. (c) 2019 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2019, 137, 48689.
机译：对弹性体及其复合材料的研究有很大兴趣，试图获得对骨组织工程中的支架材料的所需生物和机械反应。已经表现出由陶瓷 - 热塑性混合物制成的复合材料，以使无机组分输送，同时不能提供靶骨组织的弹性蛋白质的替代品，即胶原蛋白。因此，为了与天然组织的固有弹性匹配，通过使用聚（甘油 - 癸二酸酯）（PGS） - β-三钙弹性体复合材料来提出含有众所周知的热塑性基质的替代物的替代物灵活性和机械完整性。本研究报告了第一次成功地挤出含有具有形状存储器特征的可生物降解复合材料的PGS。所得结构物理和化学表征。通过使用MC3T3-E1小鼠预燕卵细胞系研究了所得材料的体外细胞培养性能。本研究中获得的材料可以通过温度刺激成形为所需的尺寸和各种形式。已经提出了所得材料用于颅面组织工程作为骨填充物，其中外科医生由于骨骼的复杂几何形状而在外科手术期间形成生物材料。 （c）2019 Wiley期刊，Inc.J.Phill。聚合物。 SCI。 2019,137,48689。

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