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首页> 外文期刊>Journal of Applied Polymer Science >Application of the Vrentas-Duda free-volume theory of diffusion below the glass-transition temperature: Application to hypromellose acetate succinate-solvent systems
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Application of the Vrentas-Duda free-volume theory of diffusion below the glass-transition temperature: Application to hypromellose acetate succinate-solvent systems

机译：在玻璃化转变温度下扩散的Vrentas-Duda自由体积理论的应用：施用乙酸乙酯酸琥珀酸溶剂 - 溶剂系统

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摘要

The Vrentas-Duda free-volume theory for diffusion characterizes the diffusivity of a solvent in a polymer in terms of the concentration and size of the solvent, the temperature, and the glass transition temperature (T-g) of the individual components. The effective T-g of the polymer, however, is a function of the concentration of the solvent. This article introduces a modification that corrects for this change in the glass-transition temperature, thus providing more accurate diffusivities. The model has been verified by comparison with experimental diffusivities of water, acetone, methanol, and tetrahydrofuran in hypromellose acetate succinate (HPMCAS). HPMCAS is widely used in the production of pharmaceutical formulations. One common application is the formation of amorphous solid dispersions with poorly soluble active pharmaceutical ingredients (APIs) for dissolution and solubility enhancement. Frequently, the APIs and HPMCAS are put into solution and spray dried at an outlet temperature below the normal glass-transition temperature. The modified free-volume theory is able to directly predict or correlate with only one adjustable parameter the diffusivities as a function of the concentration and temperature. (c) 2018 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2019, 136, 47351.
机译：扩散用的Vrentas-杜达自由体积理论表征在聚合物中的溶剂的扩散性在浓度和溶剂，温度的大小，和单个组分的玻璃化转变温度（T-G）的条款。聚合物的有效T-克，但是，是在溶剂的浓度的函数。本文介绍了一个修饰在玻璃化转变温度这一变化进行校正，从而提供更精确的扩散率。该模型已被用在羟丙甲纤维素乙酸酯琥珀酸酯的水，丙酮，甲醇和四氢呋喃实验扩散率（HPMCAS）比较验证。 HPMCAS被广泛用于生产药物制剂。一个常见的应用是无定形固体分散体与溶解和溶解度的提高难溶的活性药物成分（API）的形成。通常，API和HPMCAS放入溶液中，在低于通常的玻璃化转变温度的出口温度喷雾干燥。修改后的自由体积理论是能够直接或预测相关成分的仅具有一个可调节的参数中扩散系数为浓度和温度的函数。 （c）2018 Wiley期刊，Inc.J.Phill。聚合物。 SCI。 2019年，136，47351。

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