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首页> 外文期刊>Journal of Applied Polymer Science >In vitro assessment of dual-network electrospun tubes from poly(1,4 cyclohexane dimethylene isosorbide terephthalate)/PVA hydrogel for blood vessel application
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In vitro assessment of dual-network electrospun tubes from poly(1,4 cyclohexane dimethylene isosorbide terephthalate)/PVA hydrogel for blood vessel application

机译：来自聚（1,4环己烷二甲基异山梨醇对苯二甲酸盐）/ PVA水凝胶的双网络电纺管管的体外评估

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摘要

The fabrication of artificial blood vessel remains an ongoing challenge for cardiovascular tissue engineering. Full biocompatibility, proper physiological, and immediate availability have emerged as central issues. To address these issues, the dual-network composite scaffolds were fabricated by coating the electrospun nanofibers-based tubes with poly(vinyl alcohol) (PVA) hydrogel, which could increase the cell viability and show the potential for controlling the composition, structure, and mechanical properties of scaffolds. Herein, the tubular scaffolds having an inner diameter of 2 mm, were composed with poly(1,4 cyclohexane dimethylene isosorbide terephthalate)/PVA. The morphology examination showed that tubular structure was dimensionally stable and suitable for an artificial blood vessel. Fourier transform infrared spectra, wetting behavior, stress-strain behavior, and Thiazolyl Blue Tetrazolium Bromide (3-(4,5-dimethylthiazol-2yl)-2,5-diphenyltetrazolium bromide) analysis also showed that the composite scaffolds have good chemical interactions between poly(1,4 cyclohexane dimethylene isosorbide terephthalate) (PICT) and PVA, blended PICT/PVA tubes showed the appropriate wetting behavior, it achieved the appropriate breaking strength and adequate pliability up to 47.5% and in vitro assessment showed that blended PICT/PVA scaffolds have the appropriate cell viability and nontoxic, respectively. On the basis of characterizations results, it was concluded that resultant scaffolds would be addressed to fulfill the requirements such as biocompatibility, dimensional stability, adequate elongation, breaking strength, immediate availability, and proper for physiologically. (c) 2018 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2019, 136, 47222.
机译：人工血管的制造仍然是心血管组织工程的持续挑战。完全生物相容性，适当的生理和立即可用性被出现为核心问题。为了解决这些问题，通过用聚（乙烯醇）（PVA）水凝胶涂覆电纺纳米纤维基管来制造双网络复合支架，这可以增加细胞活力并显示控制组成，结构和控制组成，结构和支架的力学性能。这里，具有2mm的内径为2mm的管状支架与聚（1,4环己烷二甲基异山梨醇对苯二甲酸盐）/ PVA组成。形态学检查表明，管状结构尺寸稳定，适用于人工血管。傅里叶变换红外光谱，润湿行为，应力 - 应变行为和噻唑基蓝四溴呢溴（3-（4,5-二甲基噻唑-200L）-2,5-二苯基四唑溴铵）分析还表明复合支架之间具有良好的化学相互作用聚（1,4环己烷二甲基异山梨醇对苯二甲酸盐）（PICT）和PVA，混合式摄像剂/ PVA管显示出适当的润湿行为，它达到了适当的断裂强度和足够的柔韧性，高达47.5％，体外评估显示混合的PICE / PVA支架分别具有适当的细胞活力和无毒。在表征结果的基础上，得出结论，将解决合成的脚手架，以满足生物相容性，尺寸稳定性，足够的伸长率，断裂强度，即时可用性和对生理学的要求等要求。 （c）2018 Wiley期刊，Inc.J.Phill。聚合物。 SCI。 2019,136,47222。

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  • 来源
    《Journal of Applied Polymer Science》 |2019年第12期|共6页
  • 作者

    Khan Muhammad Qamar; Kharaghani Davood; Nishat Nazish; Sanaullah; Shahzad Amir; Yamamoto Takayuki; Inoue Yuma; Kim Ick Soo;

  • 作者单位

    Shinshu Univ Fac Text Sci Interdisciplinary Cluster Cutting Edge Res ICCER Div Frontier Fiber Inst Fiber Engn Tokida 3-15-1 Ueda Nagano 3868567 Japan;

    Shinshu Univ Fac Text Sci Interdisciplinary Cluster Cutting Edge Res ICCER Div Frontier Fiber Inst Fiber Engn Tokida 3-15-1 Ueda Nagano 3868567 Japan;

    Bahauddin Zakariya Univ Multan Inst Pure &

    Appl Biol Multan 66000 Punjab Pakistan;

    Shinshu Univ Fac Text Sci Interdisciplinary Cluster Cutting Edge Res ICCER Div Frontier Fiber Inst Fiber Engn Tokida 3-15-1 Ueda Nagano 3868567 Japan;

    Natl Text Univ Fac Engn Electrospun Mat &

    Polymer Membranes Res Grp Shaikhupura Rd Faisalabad 37610 Pakistan;

    Shinshu Univ Fac Text Sci Interdisciplinary Cluster Cutting Edge Res ICCER Div Frontier Fiber Inst Fiber Engn Tokida 3-15-1 Ueda Nagano 3868567 Japan;

    Shinshu Univ Fac Text Sci Interdisciplinary Cluster Cutting Edge Res ICCER Div Frontier Fiber Inst Fiber Engn Tokida 3-15-1 Ueda Nagano 3868567 Japan;

    Shinshu Univ Fac Text Sci Interdisciplinary Cluster Cutting Edge Res ICCER Div Frontier Fiber Inst Fiber Engn Tokida 3-15-1 Ueda Nagano 3868567 Japan;

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 高分子化合物工业（高聚物工业）;
  • 关键词

    artificial blood vessel; dual-network composite; electrospun nanofibers tube; PVA hydrogel; scaffolds;

    机译：人工血管;双网络复合材料;Electrome纳米纤维管;PVA水凝胶;脚手架;

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