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首页> 外文期刊>Journal of Applied Polymer Science >Development of gelatin/chitosan/PVA hydrogels: Thermal stability, water state, viscoelasticity, and cytotoxicity assays
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Development of gelatin/chitosan/PVA hydrogels: Thermal stability, water state, viscoelasticity, and cytotoxicity assays

机译：明胶/壳聚糖/ PVA水凝胶的研制：热稳定性，水状态，粘弹性和细胞毒性测定

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摘要

Gelatin/chitosan/poly(vinyl alcohol) (PVA) hydrogels were fabricated with different polymer ratio using the freeze-drying process. The thermal stability, water state, rheological, and cytotoxic properties of the hydrogels were evaluated. Thermogravimetric/differential scanning calorimetry analyses showed a decomposition onset temperature below 242.7 +/- 2.7 degrees C. The samples did not show statistical differences (p 0.05) on the onset temperature values. Nonfreezing water reached a constant value around of 1 g water/g polymer. Freezing water increased linearly with the increase of the water content independently of the polymer ratio. The hydrogels showed an equilibrium water content from 9 to 13 times their mass. The hydrogels exhibited a solid-viscoelastic behavior. The elastic modulus was higher with the increase of chitosan concentration (G ' = 22 170 +/- 85 Pa) independently of the temperature (5-55 degrees C). In vitro assay showed that hydrogels are nontoxic in the HT29-MTX-E12 cell line. These results indicate that the gelatin/chitosan/PVA hydrogels could be considered for biomedical applications. (c) 2018 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2019, 136, 47149.
机译：使用冷冻干燥过程，用不同的聚合物比制造明胶/壳聚糖/聚（乙烯醇）（PVA）水凝胶。评价水凝胶的热稳定性，水状态，流变学和细胞毒性特性。热重扫描/差示扫描量热法分析显示出低于242.7 +/- 2.7℃的分解起始温度。样品在开始温度值上没有显示出统计差（P <0.05）。非羊水水达到1g水/ g聚合物的恒定值。通过独立于聚合物比例的水含量随着水含量的增加而线性增加了冷冻水。水凝胶显示出9至13倍的平衡水含量。水凝胶表现出固体粘弹性行为。随着温度（5-55℃）的壳聚糖浓度（G'= 22 170 +/- 85Pa）的增加，弹性模量较高。体外测定表明，HT29-MTX-E12细胞系中的水凝胶无毒。这些结果表明明胶/壳聚糖/ PVA水凝胶可考虑生物医学应用。 （c）2018 Wiley期刊，Inc.J.Phill。聚合物。 SCI。 2019,136,47149。

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