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Continuous and high throughput production of alginate fibers using co-flow in a millifluidic T-junction

机译:使用毫流T型交界处的杂交纤维的连续和高通量产生藻酸盐纤维

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摘要

We present a new technique for continuous production of alginate fibers using off-the-shelf millifluidic components and syringe pumps. The components are quickly assembled to form a T-junction to deliver co-flowing streams of sodium alginate and calcium chloride allowing formation of hydrogel fibers in the exit channel. We vary the flow rates of the two streams, calcium chloride concentrations and length of exit channel and identify conditions where fibers of uniform and nonuniform thickness are produced. We find that uniform fibers can be produced at a maximum total flow rate of 10 mLmin(-1). As expected, for uniform fibers, we observe that the fiber diameter increases with increase in alginate solution flow rate, and we propose a simple model that predicts the fiber diameter as a function of flow rate ratio. We investigate the source of fiber nonuniformity and explain it using an empirical model that involves crosslinking time and gel strength. Our approach features easy device assembly and operation and enables continuous fiber production without clogging risks. Fiber production rates in the order of 10 mmin(-1) are achievable using our approach. (c) 2018 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2019, 136, 47120.
机译:我们提出了一种使用现成的毫流组件和注射泵连续生产藻酸盐纤维的新技术。迅速组装成分以形成T型结,以递送藻酸钠和氯化钙的共流流,允许在出口通道中形成水凝胶纤维。我们改变了两个流,氯化钙浓度和出口通道长度的流速,并鉴定产生均匀和不均匀厚度的纤维的条件。我们发现可以在10mLmin(-1)的最大总流速下产生均匀的纤维。正如预期的那样,对于均匀的纤维,我们观察到纤维直径随着藻酸盐溶液流速的增加而增加,并且我们提出了一种简单的模型,该模型预测纤维直径作为流速比的函数。我们研究了纤维不均匀的来源,并使用涉及交联时间和凝胶强度的经验模型来解释它。我们的方法具有易于设备组装和操作,可实现连续光纤生产而不会堵塞风险。使用我们的方法可以实现10 mmin(-1)的纤维生产率。 (c)2018 Wiley期刊,Inc.J.Phill。聚合物。 SCI。 2019,136,47120。

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