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首页> 外文期刊>Journal of Applied Polymer Science >Molecularly imprinted polymer microspheres prepared via the two-step swelling polymerization for the separation of lincomycin
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Molecularly imprinted polymer microspheres prepared via the two-step swelling polymerization for the separation of lincomycin

机译：通过两步溶胀聚合制备的分子印迹聚合物微球用于分离林霉素

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摘要

A molecularly imprinted polymer (MIP) was synthesized via a two-step swelling polymerization method for the purification of lincomycin. Polystyrene microspheres were prepared by the dispersion-polymerization process and used as the substrate. Methacrylic acid was used as the functional monomer, whereas ethylene glycol dimethacrylate was the cross-linker. The MIP was structurally characterized and examined for its separation performance at different conditions (temperature, solvents, etc.). It was found that the MIP possesses the good sphericity, porosity, monodispersity, and a high adsorption capacity of (180 mu mol/g) in chloroform solution. Comparison studies showed that the MIP presents a higher capacity than the NIP (non-imprinted polymer) in chloroform solution and a much higher capacity in the practical lincomycin fermentation solution extracts, confirming the underlining mechanisms of the MIP. Scatchard plot revealed two adsorption mechanisms on the MIP, whereas the isotherm is better described by Freundlich equation. The adsorption/elution kinetics demonstrated that the MIP possesses good elution/regeneration capabilities with the elution ratio > 93%. (c) 2019 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2019, 136, 47938.
机译：通过两步溶胀聚合方法合成分子印迹聚合物（MIP），用于纯化LiNcomcin。聚苯乙烯微球通过分散聚合方法制备并用作基材。使用甲基丙烯酸作为官能单体，而乙二醇二甲基丙烯酸酯是交联剂。在结构上进行结构表征和检查其在不同条件下的分离性能（温度，溶剂等）。发现壁壁具有良好的球形性，孔隙率，单分散性和氯仿溶液中（180μmol/ g）的高吸附能力。比较研究表明，MIP比氯仿溶液中的辊染力（非印迹聚合物）呈现更高的容量，并且在实际的林核霉素发酵溶液提取物中具有更高的容量，确认了MIP的下划线机制。 Scatchard Plot在MIP上显示了两个吸附机制，而Freundlich方程更好地描述了等温。吸附/洗脱动力学证明，MIP具有良好的洗脱/再生能力，洗脱比> 93％。 （c）2019 Wiley期刊，Inc.J.Phill。聚合物。 SCI。 2019,136,47938。

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