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首页> 外文期刊>Journal of Applied Polymer Science >Long time release of water soluble drug from hydrophilic nanofibrous material
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Long time release of water soluble drug from hydrophilic nanofibrous material

机译：来自亲水性纳米纤维材料的长时间释放水溶性药物

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摘要

In this study, mesoporous silica nanoparticles (MSNs) were embedded into the hydrophilic poly(vinyl alcohol) (PVA) nanofibrous mats to achieve sustained release of water soluble drug from hydrophilic nanofibrous mats. MSNs were successfully prepared based on a sol-gel method. Water soluble drug naproxen sodium was then loaded into the mesopores of the MSNs, and different amounts of the drug-loaded MSNs were further incorporated into the fibers by the electrospinning process. Morphology of the nanofibrous mats was investigated, and it was found that all the fibers exhibited fibrous structure. Interestingly, lots of protrusions could be observed from the scanning electron microscopy images with high magnification, and numbers of the protrusions increased with the increasing of loading ratios of the MSNs from 5 to 15%. In addition, the wetting behaviors of the nanofibrous mats were also measured, and the water contact angles of all the mats were measured to be 0 degrees. Finally, the drug release results indicated that all the PVA/MSNs composite nanofibrous mats showed an obviously prolonged drug release. The optimal loading ratio of the MSNs in the nanofibers was 10% due to the slowest drug release rate. (c) 2019 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2019, 136, 47922.
机译：在该研究中，将中孔二氧化硅纳米颗粒（MSN）嵌入亲水性聚（乙烯醇）（PVA）纳米纤维垫中，以实现来自亲水纳米纤维垫的水溶性药物的持续释放。基于溶胶 - 凝胶法成功准备了MSN。然后将水溶性药物萘啶钠加载到MSN的中孔中，并且通过电刺刀法进一步掺入纤维中的不同量的药物制备。研究了纳米纤维垫的形态，发现所有纤维表现出纤维结构。有趣的是，可以从具有高放大率的扫描电子显微镜图像中观察到大量突起，并且突起的数量随着MSN的加载比率的增加，从5到15％增加。另外，还测量纳米纤维垫的润湿行为，并测量所有垫的水接触角为0度。最后，药物释放结果表明所有PVA / MSNS复合纳米纤维垫显示出明显延长的药物释放。由于药物释放速率最慢，纳米纤维中MSN的最佳负载比率为10％。 （c）2019 Wiley期刊，Inc.J.Phill。聚合物。 SCI。 2019,136,47922。

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  • 来源
    《Journal of Applied Polymer Science》 |2019年第36期|共9页
  • 作者

    Pan Nan; Qin Juanrong; Fan Yuwei; Li Zeke; Song Botao;

  • 作者单位

    Northwest Univ Coll Chem &

    Mat Sci Minist Educ Key Lab Synthet &

    Nat Funct Mol Chem Xian 710069 Shaanxi Peoples R China;

    Northwest Univ Coll Chem &

    Mat Sci Minist Educ Key Lab Synthet &

    Nat Funct Mol Chem Xian 710069 Shaanxi Peoples R China;

    Northwest Univ Coll Chem &

    Mat Sci Minist Educ Key Lab Synthet &

    Nat Funct Mol Chem Xian 710069 Shaanxi Peoples R China;

    Northwest Univ Coll Chem &

    Mat Sci Minist Educ Key Lab Synthet &

    Nat Funct Mol Chem Xian 710069 Shaanxi Peoples R China;

    Northwest Univ Coll Chem &

    Mat Sci Minist Educ Key Lab Synthet &

    Nat Funct Mol Chem Xian 710069 Shaanxi Peoples R China;

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 高分子化合物工业（高聚物工业）;
  • 关键词

    electrospinning; hydrophilic; mesoporous silica; PVA; sustained release;

    机译：静电纺丝;亲水;中孔二氧化硅;PVA;持续释放;

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