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首页> 外文期刊>Journal of Applied Polymer Science >NIR light-triggered gelling in situ of porous silicon nanoparticles/PEGDA hybrid hydrogels for localized combinatorial therapy of cancer cells
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NIR light-triggered gelling in situ of porous silicon nanoparticles/PEGDA hybrid hydrogels for localized combinatorial therapy of cancer cells

机译：NIR光触发的多孔硅纳米粒子/ PEGDA杂交水凝胶的原位抗癌细胞癌细胞的局部组合治疗

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摘要

Porous silicon-based nanocomposite hydrogels were readily constructed with the gelation of poly(ethylene glycol) double acrylates (PEGDA) macromers, due to the initiation of singlet oxygen photosensitized with porous silicon nanoparticles (PSiNPs) under near-infrared (NIR) light irradiation. Multifunctional PSiNPs/PEGDA nanocomposite hydrogels showed strong fluorescence, excellent biodegradability, significant photothermal effect, and sustained drug release with high efficiency (80%). Finally, in situ growth of PSiNPs/PEGDA hybrid hydrogels on cancer cells was also achieved by NIR light, and then their biodegradation, drug release and synergistic chemo-phototherapeutic efficacy were further demonstrated, which could provide a significant localized inhibition for the viability, adherence, and migration of cancer cells in vitro. Thus, we suggested that these resultant hybrid hydrogels would have important potential on local cancer therapy in future clinical practice. (c) 2018 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2019, 136, 47443.
机译：用聚（乙二醇）双丙烯酸酯（PEGDA）大分子体的凝胶化容易地构建多孔硅基纳米复合水凝胶，因为在近红外（NIR）光照射下与多孔硅纳米颗粒（PSINP）感光的单次氧气引发。多功能Psinps / PEGDA纳米复合水凝胶显示出强大的荧光，优异的生物降解性，显着的光热效应，以及高效率（＆ 80％）的持续药物释放。最后，通过Nir光还达到了Psinps / PEGDA杂交水凝胶的psinps / PEGDA杂交水凝胶，然后进一步证明了它们的生物降解，药物释放和协同化学光照学效果，这可以为生存能力，粘附性提供显着的局部抑制和体外癌细胞迁移。因此，我们建议这些所得杂交水凝胶在未来临床实践中对局部癌症治疗具有重要潜力。 （c）2018 Wiley期刊，Inc.J.Phill。聚合物。 SCI。 2019,136,47443。

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