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首页> 外文期刊>Journal of Applied Polymer Science >Biocompatible palm stearin-based polyesteramide as polymer carrier for solid dispersion
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Biocompatible palm stearin-based polyesteramide as polymer carrier for solid dispersion

机译：基于生物相容性的棕榈树脂基聚酯酰胺作为聚合物载体用于固体分散体

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摘要

Palm stearin-based polyesteramide (PSPEA) was synthesized by reacting PS with diethanolamine, followed by azelaic acid at functionality molar ratio (OH:COOH) ranged 1:0.84 to 1:0.95 at 150-190 degrees C. FTIR, H-1-nuclear magnetic resonance, C-13-nuclear magnetic resonance, and gel permeation chromatography were used to elucidate the chemical structure and M-w distribution of the PSPEA. PSPEA 4000 (acid value = 0.61 mg KOH/g sample, hydroxyl value = 51.97 mg KOH/g sample) was used in combination with stearic acid-based PEA to prepare mefenamic acid (MA) solid dispersion. The solid dispersion demonstrated sixfold and twofold enhancement in T-50% and cumulative drug release as compared to pure MA. The differential scanning calorimetry and scanning electron microscopy analyses revealed solubilization of MA in PEA and transformation of MA into amorphous. In vitro cytotoxicity studies confirmed the safety profile of PSPEA against 3T3 fibroblast cell lines. This work demonstrated that the biocompatible PSPEA possesses surface tension lowering and anticrystallization effects have the potential as polymer carrier for pharmaceutical dosage forms. (C) 2017 Wiley Periodicals, Inc.
机译：通过用二乙醇胺反应合成棕榈树脂基聚酯酰胺（PSPEA），然后在官能度摩尔比（OH：COOH）下偶氮酸（OH：COOH），范围为1：0.84至1：0.95，在150-190℃。FTIR，H-1-核磁共振，C-13核磁共振和凝胶渗透色谱法用于阐明PSPEA的化学结构和MW分布。 PSPEA 4000（酸值= 0.61mg KOH / G样品，羟值= 51.97mg KOH / G样品）与硬脂酸基豌豆组合使用，以制备挥发性酸（MA）固体分散体。与纯MA相比，固体分散体在T-50％的T-50％和累积药物释放中表现出六倍和双重增强。差分扫描量热法和扫描电子显微镜分析显示MA在豌豆中的溶解和MA的转化为无定形。体外细胞毒性研究证实了PSPEA对3T3成纤维细胞系的安全性曲线。这项工作表明，生物相容性PSPEA具有表面张力降低和抗混合效应具有用于药物剂型的聚合物载体的潜力。 （c）2017 Wiley期刊，Inc。

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