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首页> 外文期刊>Journal of Applied Polymer Science >Influence of carboxyl and amide groups on in vitro hemocompatibility of sulfonated polypropylene non-woven fabric
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Influence of carboxyl and amide groups on in vitro hemocompatibility of sulfonated polypropylene non-woven fabric

机译：羧基和酰胺基对磺化聚丙烯非织造织物体外血液相色的影响

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摘要

The sulfonated polypropylene non-woven fabric (PPNWF) was successfully fabricated via gamma-ray simultaneous radiationinduced graft polymerization of acrylic acid (AA)/sodium styrenesulfonate (NaSS) and acrylamide (AAm)/NaSS. The existence of graft chains in both PP-g-P(AA-co-NaSS) and PP-g-P(AAm-co-NaSS) was proved by attenuated total reflection Fourier transform infrared spectroscopy and X-ray photoelectron spectroscopy. Water contact angle measurement illustrated the sulfonated PPNWF owning good hydrophilicity. The in vitro hemocompatibility evaluation showed that both PP-g-P(AA-co-NaSS) and PP-g-P(AAm-co-NaSS) inhibited effectively the adhesion of platelets and were significantly compatible with erythrocytes. Moreover, no obvious difference was confirmed in the prevention of platelet adhesion and hemolysis ratio between carboxyl and amide groups. However, as compared with that of PP-g-P(AAm-co-NaSS), PP-g-P(AA-co-NaSS) exhibited outstanding anticoagulant activity via increased activated partial thromboplastin time and thrombin time. This result indicated that the carboxyl group but not amide group featured strong synergistic effect on the anticoagulant activity of sulfonated PPNWF. (C) 2017 Wiley Periodicals, Inc.
机译：通过丙基射线同时辐射辐射的接枝聚合成功制造磺化聚丙烯非织造织物（PPNWF）的丙烯酸（AA）/苯乙烯磺酸钠（NASS）和丙烯酰胺（AAM）/ NASS。通过减弱的总反射傅里叶变换红外光谱和X射线光电子谱证明，通过减弱的全反射傅里叶变换和X射线光电子谱证实了PP-G-P（AA-Co-NASS）和PP-G-P（AAM-Co-NASS）中的接枝链的存在。水接触角测量说明了具有良好亲水性的磺化PPNWF。体外血液相容性评价显示PP-G-P（AA-Co-NASS）和PP-G-P（AAM-Co-NASS）有效地抑制了血小板的粘附性，并且与红细胞显着相容。此外，在预防羧基和酰胺基团之间的血小板粘附和溶血比中没有确认明显差异。然而，与PP-G-P（AAM-Co-NASS）相比，PP-G-P（AA-Co-NASS）通过增加的活性部分血栓形成时间和凝血酶时间表现​​出优异的抗凝血活性。该结果表明，羧基但不是酰胺基团对磺化PPNWF的抗凝血活性具有强烈的协同作用。 （c）2017 Wiley期刊，Inc。

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