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首页> 外文期刊>Journal of Applied Polymer Science >Biocompatible, stimuli-responsive hydrogel of chemically crosslinked beta-cyclodextrin as amoxicillin carrier
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Biocompatible, stimuli-responsive hydrogel of chemically crosslinked beta-cyclodextrin as amoxicillin carrier

机译：化学交联β-环糊精的生物相容性，刺激浓度水凝胶作为Amoxicillin载体

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摘要

A novel pH-responsive, chemically crosslinked hydrogelator (cl-beta-CD/pVP) has been fabricated using beta-cyclodextrin (beta-CD) and N-vinyl pyrollidone (N-VP) in presence of diurethane dimethacrylate (DUDMA) crosslinker/azobisisobutyronitrile initiator through free radical polymerization. Various grades of cl-beta-CD/pVP have been synthesized and the best grade has been considered with higher crosslinking density, higher gel strength, and lower % swelling ratio. The hydrogelator has been characterized by FTIR, H-1 and C-13 NMR spectroscopy, TGA, and FESEM analyses. The hydrogelator demonstrates pH-responsive behavior, which has been confirmed by swelling behavior and gel characteristics at various pH (at 37 degrees C). Using hen egg lysozyme, degradation experiment has been performed, which confirms the biodegradable nature of the hydrogel. The in vitro cytotoxicity study and live-dead assay suggest that the hydrogelator is cytocompatible toward MG-63 cells. Finally, the hydrogelator shows excellent efficacy as an antibiotic (amoxicillin) carrier. (C) 2017 Wiley Periodicals, Inc.
机译：使用β-环糊精（β-CD）和N-乙烯基聚rollidone（N-VINGEL PYROLLIDONE（N-VP）在基亚氨基甲酸二丙烯酸酯（DUDMA）交联剂/偶氮二异丁腈引发剂通过自由基聚合。已经合成了各种等级的Cl-Beta-CD / PVP，并且已经考虑了具有较高交联密度，更高的凝胶强度和较低的溶胀比的最佳等级。该水凝胶形成剂的特点是FTIR，H-1和C-13 NMR光谱，TGA，和FESEM分析。水凝胶器证明了pH-响应行为，其通过溶胀行为和各种pH（37℃）的凝胶特性证实。使用母鸡蛋溶菌酶，已经进行了降解实验，证实了水凝胶的可生物降解性质。体外细胞毒性研究和活死测定表明，水胶素是对Mg-63细胞的细胞栓塞。最后，水凝胶剂显示出优异的效果作为抗生素（Amoxicillin）载体。 （c）2017 Wiley期刊，Inc。

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