• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Journal of Applied Polymer Science >PCEC hydrogel used on sustained-release hyaluronic acid delivery with lubrication effect
【24h】

PCEC hydrogel used on sustained-release hyaluronic acid delivery with lubrication effect

机译：PCEC水凝胶用于持续释放的透明质酸输送，润滑效应

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Injection of bionic synovial fluid (BSF) is a conventional method to improve the lubricity of artificial joints, but BSF cannot maintain long due to the dilution and degradation of BSF in human body. To prolong the effectiveness of hyaluronic acid (HA), which is the major component of BSF, this study applies a temperature-sensitive poly(-caprolactone)-poly(ethylene glycol)-poly(-caprolactone) (PCEC) hydrogel loaded with HA to achieve long-term lubrication. In addition, Fourier transform infrared, nuclear magnetic resonance analysis, X-ray diffraction, scanning electron microscopy (SEM), and gel permeation chromatography spectra were used to analyze the structure of the synthetic hydrogel. Rheological test and test tube inverting method were used to characterize the thermosensitivity. The lubrication properties of the released solution were characterized by UV-vis, tribological tests, SEM, and 3D laser confocal scanning microscope. The experimental results reveal that the triblock PCEC hydrogel contains both hydrophilic block and hydrophobic block, and both PCEC and PCEC/HA hydrogels have phase-changed effect when the temperature increases from room temperature to body temperature. Moreover, the friction coefficient of the released solution from PCEC/HA hydrogel is approximatively 38% lower than that of phosphate buffer saline. And the ability of shear resistance and creep recovery of PCEC/HA hydrogel are better than that of PCEC hydrogel. This study provides an effective approach to achieve long-time lubrication effect for artificial joints. (c) 2018 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2018, 135, 46228.
机译：注射仿生滑膜（BSF）是改善人工关节润滑性的常规方法，但由于BSF在人体中BSF的稀释和降解，BSF不能保持长度。为了延长透明质酸（HA）的有效性，这是BSF的主要成分，本研究适用于载有HA的温度敏感的聚（ - 乙二醇）-poly（ - 乙二醇）（ - 乙二醇）水凝胶实现长期润滑。另外，使用傅里叶变换红外，核磁共振分析，X射线衍射，扫描电子显微镜（SEM）和凝胶渗透色谱光谱来分析合成水凝胶的结构。流变测试和试管反相方法用于表征热敏敏感性。释放溶液的润滑性质的特征是通过UV-Vis，摩擦学试验，SEM和3D激光共焦扫描显微镜。实验结果表明，三嵌段PCEC水凝胶含有亲水嵌段和疏水嵌段，并且当温度从室温增加到体温时，PCEC和PCEC / HA水凝胶都具有相变效应。此外，来自PCEC / HA水凝胶的释放溶液的摩擦系数比磷酸盐缓冲盐的38％显着38％。并且PCEC / HA水凝胶的剪切抗性和蠕变恢复的能力优于PCEC水凝胶。本研究提供了一种有效的方法来实现人工关节的长期润滑效果。 （c）2018 Wiley期刊，Inc.J.Phill。聚合物。 SCI。 2018,135,46228。

著录项

  • 来源
    《Journal of Applied Polymer Science》 |2018年第22期|共10页
  • 作者

    Guo Junde; Li Yue; Lu Hailin; Li Yu; Li Xing; Qin Liguo; Dong Guangneng;

  • 作者单位

    Xi An Jiao Tong Univ Sch Mech Engn Key Lab Educ Minist Modern Design &

    Rotor Bearing Syst Xian 710049 Shaanxi Peoples R China;

    Xi An Jiao Tong Univ Sch Mech Engn Key Lab Educ Minist Modern Design &

    Rotor Bearing Syst Xian 710049 Shaanxi Peoples R China;

    Xi An Jiao Tong Univ Sch Mech Engn Key Lab Educ Minist Modern Design &

    Rotor Bearing Syst Xian 710049 Shaanxi Peoples R China;

    Xi An Jiao Tong Univ Dept Appl Chem Sch Sci Xian 710049 Shaanxi Peoples R China;

    Xi An Jiao Tong Univ Sch Mech Engn Key Lab Educ Minist Modern Design &

    Rotor Bearing Syst Xian 710049 Shaanxi Peoples R China;

    Xi An Jiao Tong Univ Sch Mech Engn Key Lab Educ Minist Modern Design &

    Rotor Bearing Syst Xian 710049 Shaanxi Peoples R China;

    Xi An Jiao Tong Univ Sch Mech Engn Key Lab Educ Minist Modern Design &

    Rotor Bearing Syst Xian 710049 Shaanxi Peoples R China;

  • 收录信息
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 高分子化合物工业（高聚物工业）;
  • 关键词

    applications; biomaterials; friction; self-assembly; wear and lubrication;

    机译：应用;生物材料;摩擦;自组装;磨损和润滑;

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号