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首页> 外文期刊>Journal of Applied Polymer Science >A dual-induced self-expandable stent based on biodegradable shape memory polyurethane nanocomposites (PCLAU/Fe3O4) triggered around body temperature
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A dual-induced self-expandable stent based on biodegradable shape memory polyurethane nanocomposites (PCLAU/Fe3O4) triggered around body temperature

机译：基于可生物降解的形状记忆聚氨酯纳米复合材料（PCLAU / FE3O4）的双诱导的自膨胀支架触发体温

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摘要

Concerning the occurrence of in-stent restenosis and stent thrombosis of stent implantation with balloon angioplasty, a dual-induced self-expandable stent based on biodegradable shape memory polyurethane nanocomposites (PCLAU/Fe3O4) was developed. The stent could maintain its temporary shape at body temperature for a certain period of time while it was able to recover to its permanent shape at the temperature a little above body temperature (around 40 degrees C) in both a water bath and an alternating magnetic field. The trigger temperature and remote local heating ensured enough operation time and harmless activation without heating the body tissue. The nanocomposites had high fixing ratios above 99% and recovery ratios above 82% at both 37 and 40 degrees C. Cytotoxicity and in vitro degradation showed the nanocomposites had good biocompatibility and biodegradability. The PCLAU/Fe3O4 nanocomposites with dual-responsive shape memory effects, desirable mechanical properties, biocompatibility, and biodegradability show great potential for vascular stents. (c) 2017 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2018, 135, 45686.
机译：关于球囊血管成形术的支架再狭窄和支架血栓形成的血液成形术，基于可生物降解的形状记忆聚氨酯纳米复合材料（PCLAU / FE3O4）的双诱导的自膨胀支架。该支架可以在体温下保持其临时形状一段时间，同时它能够在水浴和交替磁场中的稍微高于体温（约40℃）的温度下恢复到其永久形状。触发温度和远程局部加热确保了足够的操作时间和无害的激活，而无需加热身体组织。纳米复合材料具有高于99％的定影比，在37和40℃的37和40℃下以上82％以上的回收率。细胞毒性和体外降解显示纳米复合材料具有良好的生物相容性和生物降解性。 PCLAU / Fe3O4纳米复合材料具有双响应形状记忆效应，理想的机械性能，生物相容性和生物降解性，对血管支架表示巨大的潜力。 （c）2017 Wiley期刊，Inc.J.Phill。聚合物。 SCI。 2018,135,45686。

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