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首页> 外文期刊>Journal of Applied Polymer Science >Ibuprofen-imprinted ultrathin poly[N-(2-hydroxypropyl) methacrylamide] films
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Ibuprofen-imprinted ultrathin poly[N-(2-hydroxypropyl) methacrylamide] films

机译：布洛芬印迹超薄超薄聚[N-（2-羟丙基）甲基丙烯酰胺]薄膜

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Surface molecularly imprinted (MIP) poly[N-(2-hydroxypropyl) methacrylamide] [poly(HPMA)] films were prepared via interface-mediated reversible addition-fragmentation chain transfer (RAFT) polymerization from 4-cyano-4-(propylsulfanylthiocarbonyl) sulfanyl pentanoic acid immobilized silicon substrate using N-(2-hydroxypropyl) methacrylamide as the functional monomer, N,N-methylene(bis)acrylamide as the crosslinking agent, and ibuprofen as the template molecule. The highly crosslinked MIP layer (approximate to 12nm) was homogeneously grafted onto the silicon surface, which favors fast mass transfer and rapid binding kinetics. Binding capacities and adsorption parameters of the MIP poly(HPMA) films were calculated from the root-mean-square roughness data obtained by atomic force microscopy measurements using the Luzinov and Langmuir equations adopted for this study. The target binding assays demonstrate the desirable binding capacity and imprinting efficiency of the MIP poly(HPMA) films. Meanwhile, the computational optimization and energy calculations showed the formation of the self-assembly of monomer and template molecule via noncovalent interactions that leads to a 1:4 molecular complex between ibuprofen and N-(2-hydroxypropyl) methacrylamide. This study provides a versatile approach to the quantitative determination of low-molecular-weight biomolecules on surface-imprinted polymers. (c) 2017 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2018, 135, 45707.
机译：表面分子印迹（MIP）聚[N-（2-羟丙基）甲基丙烯酰胺] [聚（HPMA）]通过从4-氰基-4-（丙基磺酰硫羰基）的界面介导的可逆添加 - 碎片链转移（筏）聚合来制备[聚（HPMA）]薄膜使用N-（2-羟丙基）甲基丙烯酰胺作为交联剂的功能单体，N，N-亚甲基（双）丙烯酰胺和布洛芬作为模板分子的二甲基丙烯酰胺固定硅衬底。高度交联的MIP层（近似为12nm）均匀地接枝到硅表面上，其利用快速传质和快速结合动力学。通过使用本研究采用的Luzinov和Langmuir方程获得的由原子力显微镜测量获得的根均方粗糙度数据计算MIP聚（HPMA）膜的粘合容量和吸附参数。靶结合测定证明了MIP聚（HPMA）膜的理想结合能力和压印效率。同时，计算优化和能量计算经由非共价相互作用表明的自组装的单体和模板分子的形成，导致1：布洛芬和N-（2-羟丙基）甲基丙烯酰胺4之间的分子复合物。该研究提供了一种多功能的方法来定量测定表面印迹聚合物上的低分子量生物分子。 （c）2017 Wiley期刊，Inc.J.Phill。聚合物。 SCI。 2018,135,45707。

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