• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Journal of Applied Polymer Science >Physicochemical properties and antimicrobial activity of biocompatible carboxymethylcellulose-silver nanoparticle hybrids for wound dressing and epidermal repair
【24h】

Physicochemical properties and antimicrobial activity of biocompatible carboxymethylcellulose-silver nanoparticle hybrids for wound dressing and epidermal repair

机译：生物相容性羧甲基纤维素 - 银纳米粒子杂交种伤口敷料和表皮修复的物理化学特性及抗微生物活性

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Skin loss can be caused by accident, burn, trauma, chronic wounds, and diseases, which is severely aggravated by multidrug-resistant bacterial infections. Soft hybrids based on biopolymers combined with silver nanoparticles (AgNPs) have potential applications as wound dressing supports and skin tissue repair. Thus, our study focused on the design, green synthesis, and comprehensive characterization of carboxymethyl cellulose (CMC-AgNP) nanocomposites for producing hydrogel membranes, with tunable physicochemical properties, cytocompatibility, and biocidal activity for potential application as wound dressing and skin repair. These nanocomposites were prepared using CMC with two degrees of carboxymethylation, distinct concentrations of citric acid (CA) crosslinker, and AgNPs by in situ chemical reduction, forming hybrid membranes by the solvent casting method. The results demonstrated that superabsorbent hydrogels were produced with swelling and degradation behaviors dependent on the concentration of CA crosslinker, degree of carboxymethylation of CMC, and content of AgNP in the matrices. Moreover, the Fourier transform infrared spectroscopy analysis evidenced that the CMC functional groups (e.g., COOH and OH) were directly involved in the chemical reactions for the formation of AgNPs and hydrogel crosslinking pathway. These nanocomposites were cytocompatible using in vitro 3-(4,5-dimethyl-2-thiazolyl)-2,5-diphenyltetrazolium bromide cell viability assay with of human embryonic kidney cells. Conclusively, the CMC-AgNP nanohybrids demonstrated to be simultaneously non-toxic combined with highly effective antibacterial activity against gram-positive multi-resistant wound/skin pathogens (Staphylococcus aureus) and moderate effect towards gram-negative strains (Escherichia coli and Pseudomonas aeruginosa). (c) 2017 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2018, 135, 45812.
机译：皮肤损失可能是由事故，烧伤，创伤，慢性伤口和疾病引起的，这被多药抗性细菌感染严重加重。基于生物聚合物的软杂种与银纳米颗粒（AgNP）合并（AgNP）具有潜在的应用，作为伤口敷料支撑件和皮肤组织修复。因此，我们的研究主要集中在设计，绿色合成，和羧甲基纤维素（CMC-AgNP）纳米复合材料用于生产水凝胶膜的综合表征，具有可调的理化性质，细胞相容性，以及潜在的应用如伤口敷料和皮肤修复杀菌活性。使用CMC制备这些纳米复合材料，其具有两度羧甲基化，不同浓度的柠檬酸（CA）交联剂，通过原位化学还原，通过溶剂浇铸方法形成杂化膜。结果表明，超吸收性水凝胶具有溶胀和降解行为，依赖于Ca交联剂的浓度，CMC的羧甲基化程度，以及基质中的AgNP含量。此外，傅里叶变换红外光谱分析证明了CMC官能团（例如，COOH和OH）直接参与形成agnps和水凝胶交联途径的化学反应。这些纳米复合材料是使用体外3-（4,5-二甲基-2-噻唑基）-2,5-二苯基四唑鎓溴化物细胞活力测定的细胞锁定，用人胚胎肾细胞使用。决定性地，展示了CMC-AgNP纳米复合物为同时无毒结合对革兰氏阳性多耐药伤口/皮肤病原体非常有效的抗菌活性（金黄色葡萄球菌）和中等程度的影响朝革兰氏阴性菌株（大肠埃希氏菌和绿脓杆菌） 。 （c）2017 Wiley期刊，Inc.J.Phill。聚合物。 SCI。 2018,135,45812。

著录项

  • 来源
    《Journal of Applied Polymer Science》 |2018年第6期|共18页
  • 作者

    Capanema Nadia S. V.; Mansur Alexandra A. P.; Carvalho Sandhra M.; Mansur Lorena L.; Ramos Carolina P.; Lage Andrey P.; Mansur Herman S.;

  • 作者单位

    Fed Univ Minas Gerais UFMG Dept Met &

    Mat Engn Ctr Nanosci Nanotechnol &

    Innovat CeNano2I Ave Antonio Carlos 6627 Escola Engn Bloco 2 BR-31270901 Belo Horizonte MG Brazil;

    Fed Univ Minas Gerais UFMG Dept Met &

    Mat Engn Ctr Nanosci Nanotechnol &

    Innovat CeNano2I Ave Antonio Carlos 6627 Escola Engn Bloco 2 BR-31270901 Belo Horizonte MG Brazil;

    Fed Univ Minas Gerais UFMG Dept Met &

    Mat Engn Ctr Nanosci Nanotechnol &

    Innovat CeNano2I Ave Antonio Carlos 6627 Escola Engn Bloco 2 BR-31270901 Belo Horizonte MG Brazil;

    Fed Univ Minas Gerais UFMG Dept Met &

    Mat Engn Ctr Nanosci Nanotechnol &

    Innovat CeNano2I Ave Antonio Carlos 6627 Escola Engn Bloco 2 BR-31270901 Belo Horizonte MG Brazil;

    Univ Fed Minas Gerais Dept Med Vet Prevent Lab Bacteriol Aplicada Escola Vet Belo Horizonte MG Brazil;

    Univ Fed Minas Gerais Dept Med Vet Prevent Lab Bacteriol Aplicada Escola Vet Belo Horizonte MG Brazil;

    Fed Univ Minas Gerais UFMG Dept Met &

    Mat Engn Ctr Nanosci Nanotechnol &

    Innovat CeNano2I Ave Antonio Carlos 6627 Escola Engn Bloco 2 BR-31270901 Belo Horizonte MG Brazil;

  • 收录信息
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 高分子化合物工业（高聚物工业）;
  • 关键词

    biocompatibility; biomaterials; biomedical applications; biopolymers and renewable polymers; polysaccharides;

    机译：生物相容性;生物材料;生物医学应用;生物聚合物和可再生聚合物;多糖;

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号