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首页> 外文期刊>Journal of Applied Polymer Science >Antimicrobial activity of PLA/PEG nanofibers containing terpinen-4-ol against Aggregatibacter actinomycetemcomitans
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Antimicrobial activity of PLA/PEG nanofibers containing terpinen-4-ol against Aggregatibacter actinomycetemcomitans

机译：PLA / PEG纳米纤维的抗菌活性含有Terpinen-4-OL对抗聚糖杆菌诱导术治疗

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摘要

In this article, nanofibrous mats of poly(lactic acid) (PLA) and poly(ethylene glycol) (PEG) with different PLA/PEG ratios were prepared by solution blow spinning. Terpinen-4-ol, a major phytoconstituent from tea tree oil (Melaleuca alternifolia) was added to the fibers and their antimicrobial activity against Aggregatibacter actinomycetemcomitans (ATCC 00078) was tested. Spun mats were characterized by scanning electron microscopy, thermogravimetric analyses, differential scanning calorimetry, Fourier-transform infrared spectroscopy (FTIR), and cell viability tests by biofilm grown on the surface of inhibitory fibers. Fibers had average diameters dependent on polymer ratio. PEG acted as a plasticizer resulting in a reduction in PLA crystallinity. Addition of PEG lead to a faster drug release. Fibrous mats with terpinen-4-ol, whose incorporation was verified by FTIR, showed an effective antimicrobial activity against A. actinomycetemcomitans, similar to those containing 0.12% chlorhexidine gluconate (P<0.05), used as both the positive control and the dose level recommended for patient treatment. These results confirm the potential of solution blow spun fibrous mats containing terpinen-4-ol in the treatment of aggressive periodontitis. (c) 2017 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2018, 135, 45782.
机译：在本文中，通过溶液吹纺制备具有不同PLA / PEG比率的聚（乳酸）（PLA）（PLA）和聚（乙二醇）和聚（乙二醇）（PEG）的纳米纤维垫。将茶树油（Melaleuca Irerficolia）的主要植物植物组合于纤维中加入Terpinen-4-OL，并对抗聚糖杆菌菌霉素（ATCC 00078）进行抗微生物活性。通过扫描电子显微镜，热重分析，差分扫描量热法，傅里叶变换红外光谱（FTIR）以及通过生物膜在抑制纤维表面上生长的生物膜的细胞活力测试的特征在于旋转垫。纤维具有依赖于聚合物比的平均直径。 PEG充当增塑剂，导致PLA结晶度还原。添加PEG导致更快的药物释放。具有Terpinen-4-Ol的纤维垫，其掺入的掺入含有FTIR的抗菌剂，对A. AltinomycetemcoLens的有效抗微生物活性，类似于含有0.12％氯己定葡萄糖酸盐（P <0.05）的抗菌剂（P <0.05），用作阳性对照和剂量水平推荐用于患者治疗。这些结果证实了含有Terpinen-4-OL的溶液吹纺纤维垫的潜力，治疗侵袭性牙周炎。 （c）2017 Wiley期刊，Inc.J.Phill。聚合物。 SCI。 2018,135,45782。

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