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首页> 外文期刊>Journal of Applied Polymer Science >Improvement of surface hydrophilicity, water uptake, biodegradability, and cytocompatibility through the incorporation of chitosan oligosaccharide into poly(l-lactide)
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Improvement of surface hydrophilicity, water uptake, biodegradability, and cytocompatibility through the incorporation of chitosan oligosaccharide into poly(l-lactide)

机译：通过将壳聚糖寡糖掺入聚（L-丙交酯），改善表面亲水性，水吸收，生物降解性和细胞锁定性

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摘要

Poly(l-lactide) (PLLA)-based biocomposites incorporated with different amounts of chitosan oligosaccharide (COS) were developed through solvent-casting method. Then, the physical-chemical properties, surface morphology, hydrophilicity, water uptake, biodegradability, and biocompatibility of the COS/PLLA composites were investigated. Fourier transform infrared and X-ray diffraction results showed that strong hydrogen-bonding interactions were presented between the COS and PLLA components. Scanning electron microscope and atomic force microscope images revealed that COS physically attached on the PLLA surface enhanced the formation of the surface seepage network, which led to the improvement of the surface biological features. A gradual rise in the level of hydrophilicity, water uptake, and degradation rate in phosphate buffered saline solution were found on increasing COS content in the COS/PLLA composites, which may provide effective support for cell adhesion and proliferation. Further, the results of cell experiments also suggested that the COS/PLLA composites had better cytocompatibility compared with PLLA. Thus, the COS/PLLA composites may have the great potential to be used for soft and bone tissue repair. (c) 2017 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2018, 135, 45724.
机译：通过溶剂浇铸法通过溶剂铸造方法制造掺入不同量的壳聚糖寡糖（COS）的聚（L-丙交酯）（PLLA）的生物复合材料。然后，研究了物理化学性质，表面形态，亲水性，水吸收，生物降解性和COS / PLLA复合材料的生物相容性。傅里叶变换红外线和X射线衍射结果表明，在COS和PLLA组分之间呈现强氢键相互作用。扫描电子显微镜和原子力显微镜图像显示COS物理上附着在PLLA表面上，增强了表面渗流网络的形成，从而改善了表面生物学特征。在COS / PLLA复合材料中的增加的COS含量增加磷酸盐缓冲盐水溶液中的亲水性，水吸收和降解速率的逐渐上升，这可以为细胞粘附和增殖提供有效的支持。此外，细胞实验的结果还表明COS / PLLA复合材料与PLLA相比具有更好的细胞相容性。因此，COS / PLLA复合材料可以具有用于软和骨组织修复的巨大潜力。 （c）2017 Wiley期刊，Inc.J.Phill。聚合物。 SCI。 2018,135,45724。

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