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首页> 外文期刊>Journal of Applied Polymer Science >Characterization of ketoprofen-loaded PEG-CH semi-IPN system for wound dressing application
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Characterization of ketoprofen-loaded PEG-CH semi-IPN system for wound dressing application

机译：卷绕敷料应用酮丁香锰加载PEG-CH半IPN系统的表征

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摘要

Polymer systems, in the form of crosslinking networks, have been widely used in biomedicine. However, they are a challenge mainly due to the impact of their physicochemical properties on release kinetics of drugs. Ketoprofen is an analgesic anti-inflammatory drug with short half-life (2 h) and quickly eliminated by the body. Topical administration of ketoprofen can reduce pain, accelerate the wound healing process, and minimize the risk of systemic side effects. Therefore, the aim was to synthesize, characterize, and evaluate a novel ketoprofen polymer system in the form of a semi-interpenetrated network of poly(ethylene glycol)-chitosan. The pore size studied by small-angle X-ray scattering showed the presence of nanoscale pores, 13.7 nm (dry state) and 26.18 nm (swollen form). The maximum swelling was 420 +/- 45% at 24 h. Finally, the encapsulated ketoprofen (6.5%) was released at a constant concentration (0.12 +/- 0.03 mg/mL, 8 h) and half of the doses up to 24 h. (c) 2018 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2018, 135, 46644.
机译：以交联网络形式的聚合物系统已被广泛用于生物医学中。然而，它们是一个挑战，主要是由于其物理化学性质对药物释放动力学的影响。 Ketoprofen是一种镇痛抗炎药，具有短半衰期（＆lt 2 h）并通过身体迅速消除。纯酮酮的局部给药可以减少疼痛，加速伤口愈合过程，并尽量减少系统副作用的风险。因此，目的是合成，表征和评价新型酮丙烯聚合物体系以半渗透网络的聚（乙二醇）-Chitosan网络的形式。小角X射线散射研究的孔径显示纳米级孔，13.7nm（干燥状态）和26.18nm（溶胀形式）存在。 24小时，最大溶胀为420 +/- 45％。最后，将包封的乙烯丁丁（6.5％）以恒定浓度（0.12 +/- 0.03mg / ml，8h）和一半剂量释放，可达24小时。 （c）2018 Wiley期刊，Inc.J.Phill。聚合物。 SCI。 2018,135,46644。

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