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首页> 外文期刊>Journal of Applied Polymer Science >pH-Sensitive pectin polymeric rafts for controlled-release delivery of pantoprazole sodium sesquihydrate
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pH-Sensitive pectin polymeric rafts for controlled-release delivery of pantoprazole sodium sesquihydrate

机译：pH-敏感果胶聚合物筏用于泮托拉唑钠钠苷的控制释放递送

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The aim of the present work was to develop pectin raft-forming tablets for controlled-release delivery of pantoprazole sodium sesquihydrate (PSS). A Box-Behnken design was used to optimize 15 formulations with three independent and three dependent variables. The physical tests of all compressed formulations were within pharmacopoeial limits. The rafts were characterized by their strength, thickness, resilience, reflux resistance, acid-neutralizing capacity, floating lag time, and total floating time. The raft strength, thickness, resilience, and reflux resistance through a 10-mm orifice of optimized formulation PR9 were 7.43 +/- 0.019g, 5.8 +/- 0.245cm, greater than 480min, and 2490 +/- 0.004g, respectively. The buffering and neutralizing capacity was 11.2 +/- 1.01 meq and 6.5 +/- 0.56 meq, respectively. Dissolution studies were performed by using simulated gastric fluid at pH1.2, and the cumulative percentage release of PR9 was found to be 97%. First-order release kinetics were followed, and non-Fickian diffusion was observed as the value of n was greater than 0.45 in the Korsmeyer-Peppas model. The Fourier transform infrared spectra of the PSS, polymers, and optimized raft formulation PR9 showed peaks at 3223.09cm(-1), 1688.17cm(-1), 1586.67cm(-1), 1302.64cm(-1), and 1027.74cm(-1) that are due to OH stretching, ester carbonyl group (CO) stretching, the existence of water and carboxylic groups in the raft, CN stretching, and OH bending vibrations and showed no interaction between them. The developed raft was suitable for sustained-release delivery of PSS. (c) 2016 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2017, 134, 44442.
机译：本工作的目的是开发用于果胶泮托拉唑钠倍半水合物（PSS）的受控释放递送筏形成片剂。使用的盒Behnken法设计具有三个独立的和三个因变量来优化15种制剂。所有压缩制剂的物理测试是药典的限度内。可以通过强度，厚度，弹性，耐回流，酸中和能力，浮滞后时间和总时间浮筏进行了表征。筏强度，厚度，弹性和回流阻力通过优化的配方PR9的10mm的孔是7.43 +/-0.019克，5.8 +/-0.245厘米，大于480min，和2490 +/-0.004克，分别。缓冲和中和能力为11.2 +/- 1.01毫当量和6.5 +/- 0.56毫当量，分别。溶出研究是通过模拟胃液在pH1.2进行，PR9的累积百分比释放被认为是97％。第一级释放动力学随访，并且观察到非菲克扩散作为n的值大于0.45的Korsmeyer-Peppas模型。傅立叶变换红外光谱的PSS，聚合物，和优化的筏制剂PR9表明在3223.09厘米峰（-1），1688.17厘米（-1），1586.67厘米（-1），1302.64厘米（-1），和1027.74厘米（-1），其是由于OH拉伸，酯羰基（CO）拉伸，水和羧基在筏的存在，CN拉伸，和OH弯曲振动并表明在它们之间没有相互作用。所开发的木筏是适合PSS的缓释交付。 （c）2016 Wiley期刊，Inc.J.Phill。聚合物。 SCI。 2017年，134，44442。

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