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首页> 外文期刊>Journal of Applied Polymer Science >Thermosensitive polymeric micelles based on the triblock copolymer poly(D,L-lactide)-b-poly(N-isopropyl acrylamide)-b-poly(D,L-lactide) for controllable drug delivery
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Thermosensitive polymeric micelles based on the triblock copolymer poly(D,L-lactide)-b-poly(N-isopropyl acrylamide)-b-poly(D,L-lactide) for controllable drug delivery

机译：基于三嵌段共聚物聚（D，L-丙交酯）-B-聚（N-异丙酰丙烯酰胺）-B-聚（D，L-丙交酯）的热敏聚合物聚合物胶束用于可控药物递送

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摘要

A thermosensitive amphiphilic triblock copolymer, poly((D),(L)-lactide) (PLA)-b-poly(N-isopropyl acrylamide) (PNIPAAM)b- PLA, was synthesized by the ring-opening polymerization of (D,L)-lactide; the reaction was initiated from a dihydroxy-terminated poly(N-isopropyl acrylamide) homopolymer (HO-PNIPAAM-OH) created by radical polymerization. The molecular structure, thermosensitive characteristics, and micellization behavior of the obtained triblock copolymer were characterized with Fourier transform infrared spectroscopy, H-1-NMR, gel permeation chromatography, dynamic light scattering, and transmission electron microscopy. The obtained results indicate that the composition of PLA-b-PNIPAAM-b-PLA was in good agreement with what was preconceived. This copolymer could self-assemble into spherical core-shell micelles (ca. 75-80 nm) in aqueous solution and exhibited a phasetransition temperature around 26 degrees C. Furthermore, the drug-delivery properties of the PLA-b-PNIPAAM-b-PLA micelles were investigated. The drug-release test indicated that the synthesized PLA-b-PNIPAAM-b-PLA micelles could be used as nanocarriers of the anticancer drug adriamycin (ADR) to effectively control the release of the drug. The drug-delivery properties of PLA-b-PNIPAAMb- PLA showed obvious thermosensitive characteristics, and the release time of ADR could be extended to 50 h. This represents a significant improvement from previous PNIPAAM-based drug-delivery systems. (C) 2017 Wiley Periodicals, Inc.
机译：通过（D，D）的开环聚合合成了热敏两组硅基三嵌段共聚物，聚（（D），（1）-Lactide）（PLA）-B-聚（N-异丙基丙烯酰胺）（PNIPAAM）B-PLA合成（ l）-Lactide;通过自由基聚合产生的二羟基封端的聚（N-异丙基丙烯酰胺）均聚物（HO-PNIPAAM-OH）开始反应。所得三嵌段共聚物的分子结构，热敏特性和胶束化行为具有傅里叶变换红外光谱，H-1-NMR，凝胶渗透色谱，动态光散射和透射电子显微镜。所得结果表明，PLA-B-Pnipaam-B-PLA的组成与先入为主的吻合吻合良好。该共聚物可以在水溶液中自组装成球状核 - 壳锭胶束（约75-80nm），并在26摄氏度约为26℃下表现出分次运动温度。此外，PLA-B-PNIPAAM-B-的药物输送性能。研究了PLA胶束。药物释放试验表明，合成的PLA-B-PNIPAAM-B-PLA胶束可以用作抗癌药物亚霉素（ADR）的纳米载体，以有效地控制药物的释放。 PLA-B-PNIPAMB - PLA的药物递送性能显示出明显的热敏特性，ADR的释放时间可以延伸至50小时。这代表了以前的基于PNIPAAM的药物输送系统的显着改善。 （c）2017 Wiley期刊，Inc。

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