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首页> 外文期刊>Journal of Applied Polymer Science >Prospects use of hybrid layered double hydroxides-polyacrylamide as controlled release media for antibiotic molecules
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Prospects use of hybrid layered double hydroxides-polyacrylamide as controlled release media for antibiotic molecules

机译：勘探用杂交层双氢氧化物 - 聚丙烯酰胺作为抗生素分子的控释介质

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摘要

Some controlled-release media containing two commercial antibiotic molecules, viz. Amoxicillin (AMX) and Ampicillin (AMP), were prepared using layered double hydroxides (LDH) intercalated and extended by polyacrylamide. The polycarylamide was prepared in situ by polymerization of acrylamide monomer intercalated in the interlayers of LDH. The LDH-polyacrylamide-antibiotic hybrid nanocomposites were characterized by various techniques like Fourier transform infrared (FT-IR), powder X-ray diffraction (XRD), thermogravimetric analysis (TGA), and field emission scanning electron microscopy (FE-SEM). The results from these characterizations have shown the successful incorporation of the antibiotics in the interlayers and provided important information regarding their interlayer structure. The nanocomposites showed increased thermal stability in TGA. The loading of antibiotic in the PAM/Mg-Al nanocomposite was found to be 36.33% for AMX and 52.38% for AMP. The improved antibacterial activity of hybrid nanocomposite was evaluated against Escherichia coli using the wells diffusion technique. The aliquot samples in agar media drug release study were found to be highly effective against microorganisms. The sustained release of antibiotic drug from the hybrid nanocomposite was also verified. The release rate at pH 7.4 phosphate buffer was found slower than that at pH 4.6. It can be concluded that hybrid nanocomposites of LDH extended by in situ polymerized acrylamide are very suitable materials to host different antibiotics and their controlled release. (c) 2017 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2017, 134, 45442.
机译：一些含有两种商业抗生素分子，VIZ的一些受控释放培养基。使用聚丙烯酰胺嵌入和延伸的层状双氢氧化物（LDH）制备Amoxicillin（AMX）和氨苄青霉素（AMP）。通过在LDH中间层中插入的丙烯酰胺单体的聚合原位原位制备聚氧酰胺。通过傅里叶变换红外（FT-IR），粉末X射线衍射（XRD），热重分析（TGA），热重分析（TGA）和场发射扫描电子显微镜（Fe-SEM）等各种技术以各种技术为特征。这些特征的结果表明，在中间层中成功掺入抗生素，并提供了关于其层间结构的重要信息。纳米复合材料在TGA中显示出热稳定性增加。发现PAM / Mg-Al纳米复合物中的抗生素的负载是AMX的36.33％，AMP的52.38％。利用孔扩散技术评估杂交纳米复合材料的改善的抗菌活性。发现琼脂培养基药物释放研究中的等分试样对微生物有效。还验证了来自杂交纳米复合材料的抗生素药物的持续释放。 pH 7.4磷酸盐缓冲液的释放速率比在pH 4.6的较慢较慢。可以得出结论，通过原位聚合的丙烯酰胺延伸的LDH的杂化纳米复合材料是非常合适的材料，以宿主不同的抗生素及其控制释放。 （c）2017 Wiley期刊，Inc.J.Phill。聚合物。 SCI。 2017,134,45442。

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