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首页> 外文期刊>Journal of Cell Science >DE-cadherin and Myosin II balance regulates furrow length for onset of polygon shape in syncytial Drosophila embryos
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DE-cadherin and Myosin II balance regulates furrow length for onset of polygon shape in syncytial Drosophila embryos

机译：脱钙蛋白和肌球蛋白II平衡调节双胞果蝇胚胎中多边形形状发作的沟槽长度

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摘要

Cell shape morphogenesis, from spherical to polygonal, occurs in epithelial cell formation in metazoan embryogenesis. In syncytial Drosophila embryos, the plasma membrane incompletely surrounds each nucleus and is organized as a polygonal epithelial-like array. Each cortical syncytial division cycle shows a circular to polygonal plasma membrane transition along with furrow extension between adjacent nuclei from interphase to metaphase. In this study, we assess the relative contribution of DE-cadherin (also known as Shotgun) and Myosin II (comprising Zipper and Spaghetti squash in flies) at the furrow to polygonal shape transition. We show that polygonality initiates during each cortical syncytial division cycle when the furrow extends from 4.75 to 5.75 mu m. Polygon plasma membrane organization correlates with increased junctional tension, increased DE-cadherin and decreased Myosin II mobility. DE-cadherin regulates furrow length and polygonality. Decreased Myosin II activity allows for polygonality to occur at a lower length than controls. Increased Myosin II activity leads to loss of lateral furrow formation and complete disruption of the polygonal shape transition. Our studies show that DE-cadherin-Myosin II balance regulates an optimal lateral membrane length during each syncytial cycle for polygonal shape transition.
机译：来自球形对多边形的细胞形状形态发生，在甲卓癌胚胎发生中的上皮细胞形成中发生。在同性恋果蝇胚胎中，血浆膜不完全围绕每个核，并被组织为多边形上皮样阵列。每个皮质合胞分裂周期显示圆形到多边形血浆膜过渡以及与间差之间的相邻核之间的沟槽延伸。在这项研究中，我们评估脱钙蛋白（也称为霰弹枪）和肌球蛋白II的相对贡献（包括拉链和苍蝇的意大利面壁球）到多边形形状转变。我们表明，当沟槽从4.75延伸到5.75亩时，多元音在每个皮质合胞分裂周期中发起。多边形等离子体膜组织与增加的连接张力增加，增加的去钙粘蛋白和降低肌蛋白II流动性。去钙粘蛋白调节沟槽长度和多元音。降低的肌球蛋白II活性允许多个间隙比对照在较低的长度下发生。增加的肌球蛋白II活性导致横向沟形成的丧失，并完全破坏多边形形状过渡。我们的研究表明，去钙粘蛋白 - 肌球蛋白II平衡在每个合成周期中调节最佳的横向膜长度，用于多边形形状转变。

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