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首页> 外文期刊>Journal of Cell Science >Ubiquitin-based modifications in endothelial cell cell contact and inflammation
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Ubiquitin-based modifications in endothelial cell cell contact and inflammation

机译：基于泛素的内皮细胞细胞接触和炎症的修饰

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Endothelial cell-cell contacts are essential for vascular integrity and physiology, protecting tissues and organs from edema and uncontrolled invasion of inflammatory cells. The vascular endothelial barrier is dynamic, but its integrity is preserved through a tight control at different levels. Inflammatory cytokines and G-protein-coupled receptor agonists, such as histamine, reduce endothelial integrity and increase vascular leakage. This is due to elevated myosin-based contractility, in conjunction with phosphorylation of proteins at cell-cell contacts. Conversely, reducing contractility stabilizes or even increases endothelial junctional integrity. Rho GTPases are key regulators of such cytoskeletal dynamics and endothelial cell-cell contacts. In addition to signaling-induced regulation, the expression of junctional proteins, such as occludin, claudins and vascular endothelial cadherin, also controls endothelial barrier function. There is increasing evidence that, in addition to protein phosphorylation, ubiquitylation (also known as ubiquitination) is an important and dynamic post-translational modification that regulates Rho GTPases, junctional proteins and, consequently, endothelial barrier function. In this Review, we discuss the emerging role of ubiquitylation and deubiquitylation events in endothelial integrity and inflammation. The picture that emerges is one of increasing complexity, which is both fascinating and promising given the clinical relevance of vascular integrity in the control of inflammation, and of tissue and organ damage.
机译：内皮细胞 - 细胞触点对于血管完整性和生理学，保护组织和器官免受水肿和不受控制的侵袭炎症细胞的必不可少的。血管内皮屏障是动态的，但它的完整性通过在不同水平的紧密控制中保存。炎症细胞因子和G蛋白偶联受体激动剂，例如组胺，降低内皮完整性并增加血管泄漏。这是由于基于肌蛋白的合成性升高，与细胞 - 细胞接触的蛋白质的磷酸化相结合。相反，减少收缩力稳定或甚至增加内皮连接完整性。 Rho GTP酶是这种细胞骨骼动力学和内皮细胞 - 细胞接触的关键调节因子。除了信号感应调节之外，结蛋白的表达，如闭塞素，克劳德汀和血管内皮钙粘蛋白，还控制内皮阻隔功能。还有越来越多的证据表明，除了蛋白质磷酸化，泛醌（也称为泛素化）是一种重要的和动态的翻译后修饰，调节Rho GTP酶，连接蛋白，并且因此内皮阻隔功能。在本次审查中，我们讨论了泛素质化和抑制性事件在内皮完整性和炎症中的新兴作用。出现的图片是越来越复杂的一种，这既令人着迷，既令人着迷，既令人着迷，鉴于血管完整在炎症和组织和器官损伤的临床相关性。

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