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首页> 外文期刊>Journal of Cell Science >Message in a vesicle - trans-kingdom intercommunication at the vector-host interface
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Message in a vesicle - trans-kingdom intercommunication at the vector-host interface

机译：在囊泡 - 跨王国在矢量主机界面处的沟通消息

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Vector-borne diseases cause over 700,000 deaths annually and represent 17% of all infectious illnesses worldwide. This public health menace highlights the importance of understanding how arthropod vectors, microbes and their mammalian hosts interact. Currently, an emphasis of the scientific enterprise is at the vector-host interface where human pathogens are acquired and transmitted. At this spatial junction, arthropod effector molecules are secreted, enabling microbial pathogenesis and disease. Extracellular vesicles manipulate signaling networks by carrying proteins, lipids, carbohydrates and regulatory nucleic acids. Therefore, they are well positioned to aid in cell-to-cell communication and mediate molecular interactions. This Review briefly discusses exosome and microvesicle biogenesis, their cargo, and the role that nanovesicles play during pathogen spread, host colonization and disease pathogenesis. We then focus on the role of extracellular vesicles in dictating microbial pathogenesis and host immunity during transmission of vector-borne pathogens.
机译：载体传播疾病每年导致超过70万人死亡，占全球所有传染病的17％。这种公共卫生威胁突出了了解节肢动物载体，微生物和哺乳动物主持人的重要性。目前，重点是科学企业处于获取和传输人类病原体的矢量主机界面。在这种空间结合条件下，节肢动物效应分子分泌，使微生物发病性和疾病能够。细胞外囊泡通过携带蛋白质，脂质，碳水化合物和调节核酸来操纵信号网络。因此，它们的定位很好地帮助细胞 - 细胞通信和介导的分子相互作用。本综述简要讨论了外来体和微溶解生物发生，其货物，以及纳米粒子在病原体蔓延期间发挥的作用，宿主定植和疾病发病机制。然后，我们专注于细胞外囊泡在载体传播病原体传播期间对微生物发病机制和宿主免疫的作用。

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