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首页> 外文期刊>Journal of Cell Science >Leishmania amazonensis hijacks host cell lysosomes involved in plasma membrane repair to induce invasion in fibroblasts
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Leishmania amazonensis hijacks host cell lysosomes involved in plasma membrane repair to induce invasion in fibroblasts

机译：Leishmania Amazonensis劫持宿主细胞溶酶体参与血浆膜修复，诱导成纤维细胞侵袭

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摘要

Intracellular parasites of the genus Leishmania are the causative agents of leishmaniasis. The disease is transmitted by the bite of a sand fly vector, which inoculates the parasite into the skin of mammalian hosts, including humans. During chronic infection the parasite lives and replicates inside phagocytic cells, notably the macrophages. An interesting, but overlooked finding, is that other cell types and even non-phagocytic cells have been found to be infected by Leishmania spp. Nevertheless, the mechanisms by which Leishmania invades such cells had not been previously studied. Here, we show that L. amazonensis can induce their own entry into fibroblasts independently of actin cytoskeleton activity, and, thus, through a mechanism that is distinct from phagocytosis. Invasion involves subversion of host cell functions, such as Ca2+ signaling and recruitment and exocytosis of host cell lysosomes involved in plasma membrane repair.
机译：Leishmania属的细胞内寄生虫是Leishmaniaisis的致病药物。 该疾病由咬粉飞载体的叮咬传播，其占寄生虫进入哺乳动物宿主的皮肤，包括人类。 在慢性感染期间，寄生虫生命并重复在吞噬细胞内，特别是巨噬细胞。 有趣但被忽视的发现是，已发现其他细胞类型甚至非吞噬细胞感染Leishmania SPP。 尽管如此，莱山姆人侵入这种细胞的机制尚未研究过。 在这里，我们表明L.Avaxonensis可以独立于肌动蛋白细胞骨架活性诱导成纤维细胞，因此通过与吞噬作用不同的机制。 侵袭涉及宿主细胞功能的颠覆，例如Ca2 +信号传导和募集和患有血浆膜修复的宿主细胞溶酶体的诱发和胞尿量。

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