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首页> 外文期刊>Journal of Colloid and Interface Science >IR780-dye loaded gold nanoparticles as new near infrared activatable nanotheranostic agents for simultaneous photodynamic and photothermal therapy and intracellular tracking by surface enhanced resonant Raman scattering imaging
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IR780-dye loaded gold nanoparticles as new near infrared activatable nanotheranostic agents for simultaneous photodynamic and photothermal therapy and intracellular tracking by surface enhanced resonant Raman scattering imaging

机译：IR780-染料负载金纳米颗粒作为新的近红外激活纳米移植剂，用于同时光动力和光热疗和通过表面增强谐振拉曼散射成像的细胞内跟踪

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Due to the good transparency of the human tissue in the biological spectral window, near-infrared (NIR)dye loaded nanosystems enable more effective light-activated therapy and better contrast imaging with major impact on nanomedicine. Herein, we prepare Pluronic coated gold nanoparticles incorporating the hydrophobic NIR dye, IR780 iodide (GNP-Plu-IR780) to provide water-solubility and stability and demonstrate the proficiency of combining photodynamic and photothermal therapeutic activity with surface-enhanced resonance Raman scattering (SERRS) imaging facility. The potential of GNP-Plu-IR780 to operate as NIR-activatable agents was first assessed in aqueous solution by singlet oxygen generation measurements and monitoring the temperature increase of the nanoparticles. Subsequent in vitro uptake studies by dark field and differential interference contrast (DIC) microscopy reveal massive internalization of GNP-Plu-IR780 by murine colon carcinoma cells (C-26). Moreover, by exploiting the SERRS effect under 785 nm laser excitation we were able to perform intracellular tracking of GNP-Plu-IR780. Finally, NIR irradiation experiments conducted in vitro against C-26 cells show efficient phototherapeutic activity induced by GNP-Plu-IR780 with no dark cytotoxicity. Moreover, when compared to the administration of free drug or non-loaded GNP-Plu, the higher phototherapeutic activity of GNP-Plu-IR780 indicates the occurrence of cooperative synergistic effects by simultaneous photodynamic and photothermal activity. (C) 2018 Elsevier Inc. All rights reserved.
机译：由于人体组织的在生物频谱窗口中的良好的透明性，近红外（NIR）染料装载纳米系统能够更有效地光活化治疗和更好的对比度成像与纳米重大影响。在此，我们准备的Pluronic涂覆的金纳米颗粒合并疏水NIR染料，IR780碘（GNP-PLU-IR780），以提供水可溶解性和稳定性并表现出具有表面增强共振拉曼散射组合光动力学和光热治疗活性的能力（SERRS ）成像设施。 GNP-PLU-IR780的电位成操作为NIR活化剂在由单线态氧生成的测量水溶液和监测纳米粒子的温度上升第一评估。由暗场和微分干涉对比（DIC）在体外摄取研究随后的显微镜揭示了通过鼠结肠癌细胞（C-26）GNP-PLU-IR780的大量内化。此外，通过下785nm的激光激发利用该SERRS效果我们能够执行GNP-PLU-IR780的细胞内跟踪。最后，在体外对C-26细胞中进行NIR照射实验表明诱导GNP-PLU-IR780没有暗毒性有效的光疗活性。此外，相对于游离药物或无负载GNP-PLU，GNP-PLU-IR780的较高光学治疗活性的施用时表示通过同时光动力和光热活性协同增效作用的发生。 （c）2018 Elsevier Inc.保留所有权利。

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