Adsorption of colloidal proteins in ion-exchange chromatography under consideration of charge regulation

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Adsorption of colloidal proteins in ion-exchange chromatography under consideration of charge regulation

机译：在考虑电荷调节下的离子交换色谱中胶体蛋白的吸附

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Mechanistic modeling of protein adsorption has gained increasing importance in the development of ion-exchange (IEX) chromatography processes. The most common adsorption models use a stoichiometric representation of the adsorption process based on the law of mass action. Despite the importance of these models in model-based development, the stoichiometric representation of the adsorption process is not accurate for the description of long-range electrostatic interactions in IEX chromatography, limiting the application and mechanistic extension of these models.

机译：蛋白质吸附的机械建模在离子交换（IEX）色谱方法的发展中获得了越来越重要的。最常见的吸附模型使用基于大规模作用规律的吸附过程的化学计量代表。尽管这些模型在基于模型的开发中的重要性，但吸附过程的化学计量表示不准确，用于描述IEX色谱中的远程静电相互作用，限制了这些模型的应用和机械延伸。

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《Journal of chromatography, A: Including electrophoresis and other separation methods》 |2020年第2020期|共10页
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正文语种 eng
中图分类分析化学;
关键词
Mechanistic modeling; Charge regulation; Resin transfer; Monoclonal antibody; Charge variants;

机译：机械造型;电荷调节;树脂转移;单克隆抗体;电荷变体;

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1. Adsorption of colloidal proteins in ion-exchange chromatography under consideration of charge regulation [J] . Journal of chromatography, A: Including electrophoresis and other separation methods . 2020,第期

机译：在考虑电荷调节下的离子交换色谱中胶体蛋白的吸附
2. Protein adsorption and transport in dextran-modified ion-exchange media. III. Effects of resin charge density and dextran content on adsorption and intraparticle uptake [J] . Bowes B.D., Lenhoff A.M. Journal of chromatography, A: Including electrophoresis and other separation methods . 2011,第40期

机译：葡聚糖修饰的离子交换介质中的蛋白质吸附和转运。三，树脂电荷密度和右旋糖酐含量对吸附和颗粒内吸收的影响
3. Electrostatic model for protein adsorption in ion-exchange chromatography and application to monoclonal antibodies, lysozyme and chymotrypsinogen A [J] . Guélat B., Str?hlein G., Lattuada M., Journal of chromatography, A: Including electrophoresis and other separation methods . 2010,第35期

机译：离子交换色谱中蛋白质吸附的静电模型及其在单克隆抗体，溶菌酶和糜蛋白酶中的应用
4. Effect of Structural Properties of Both Proteins and Stationary Phases to Adsorption Behavior of Proteins in Hydrophobic Interaction Chromatography [C] . Ren Jun, Pi Zhiqian, Lin Xue, 2010 4th International Conference on Bioinformatics and Biomedical Engineering . 2010

机译：疏水相互作用色谱中蛋白质和固定相的结构性质对蛋白质吸附行为的影响
5. Adsorption of polyelectrolyte on colloidal silica: Patchwise adsorption vs. charge regulation. [D] . Shin, YongWoo. 2001

机译：聚电解质在胶体二氧化硅上的吸附：分批吸附与电荷调节。
6. Protein adsorption and transport in dextran-modified ion-exchange media. III. Effects of resin charge density and dextran content on adsorption and intraparticle uptake [O] . Brian D. Bowes, Abraham M. Lenhoff -1

机译：葡聚糖改性离子交换介质中的蛋白质吸附和转运。 III。树脂电荷密度和葡聚糖含量对吸附和骨盆内摄取的影响
7. Protein adsorption and transport in dextran-modified ion-exchange media. III. Effects of resin charge density and dextran content on adsorption and intraparticle uptake [O] . Brian D. Bowes, Abraham M. Lenhoff 2011

机译：葡聚糖改性离子交换介质中的蛋白质吸附和转运。 III。树脂电荷密度和葡聚糖含量对吸附和骨盆内摄取的影响

Adsorption of colloidal proteins in ion-exchange chromatography under consideration of charge regulation

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