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首页> 外文期刊>Journal of chromatography, A: Including electrophoresis and other separation methods >A target integration strategy for analyzing multidimensional chemical and metabolic substance groups of Ding-Zhi-Xiao-Wan prescription by using ultra-high performance liquid chromatography tandem mass spectrometry
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A target integration strategy for analyzing multidimensional chemical and metabolic substance groups of Ding-Zhi-Xiao-Wan prescription by using ultra-high performance liquid chromatography tandem mass spectrometry

机译：用超高效液相色谱串联质谱法分析丁志法湾丁志湾湾处方多维化学和代谢物质组的目标整合策略

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摘要

It is both challenging and meaningful for identifying the in vivo metabolites of the complex prescription owning to more complex chemical constituents and better therapeutic effect than those of the single medicine. In this paper, a target integration strategy combined with tandem mass spectrometry technology was developed for identification of metabolites from monomer composition of representative standard to Ding-Zhi-Xiao-Wan prescription (DZXW). The representative standards of each type in DZXW were utilized fully to explore the rule of mass fragmentation and the metabolism in vitro. These study were then extended to the single medicine and finally to the DZXW prescription. In addition, the order of metabolic research followed the metabolic order of oral drug in body, namely from in vitro, to intestine tract, to liver, to blood, and ultimately to target organs. As a result, a total of 150 prototypes and 51 metabolites of DZXW were effectively detected and identified in vivo. This result laid a material foundation for the better application of DZXW in treating Alzheimer's disease. More importantly, this analysis strategy provided a deep insight for the drug metabolism of traditional Chinese medicine. (C) 2019 Elsevier B.V. All rights reserved.
机译：它既是具有挑战性的，有意义的用于识别比单一药物的在复处方拥有到更复杂的化学成分的体内代谢物和更好的治疗效果。在本文中，开发了一种与串联质谱技术相结合的目标整合策略，用于鉴定来自代谢物的代谢物，从代表标准中的单体组合物到Ding-Xiao-WAN处方（DZXW）。 DZXW中每种类型的代表性标准充分利用，探讨质量碎片和体外代谢的规则。然后将这些研究扩展到单一药物，最后达到DZXW处方。此外，代谢研究的顺序遵循身体中口腔药物的代谢顺序，即在体外，肠道到肝脏，血液，最终对靶器官。其结果是，共150个原型和DZXW 51种代谢物有效地检测和体内鉴定。该结果为DZXW在治疗阿尔茨海默病方面奠定了一种材料基础。更重要的是，这种分析策略为中药的药物代谢提供了深入的洞察力。 （c）2019 Elsevier B.v.保留所有权利。

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