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首页> 外文期刊>Journal of chromatography, A: Including electrophoresis and other separation methods >Tolerance intervals modeling for design space of a salt assisted liquid-liquid microextraction of trimethoprim and six common sulfonamide antibiotics in environmental water samples
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Tolerance intervals modeling for design space of a salt assisted liquid-liquid microextraction of trimethoprim and six common sulfonamide antibiotics in environmental water samples

机译：盐辅助液体微萃取设计空间的耐受间隔模型，环境水样中的六种常见的磺胺酰胺抗生素

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Sulfonamides and trimethoprim combinations have been used extensively as antimicrobial agents for prevention and treatment of human and animal infections. Although many microextraction methods were developed for monitoring their residues in environmental water, none of these methods applied liquid-liquid microextraction for this purpose. This work presents for the first time a simultaneous Salt Assisted Liquid-Liquid Microextraction SALLME coupled with HPLC-UV for determination of trimethoprim and six common sulfonamide residues (sulfathiazole, sulfadiazine, sulfadmidine, sulfamethoxazole sulfadoxine and sulfaquinoxaline) in water samples. Co-extraction of trimethoprim with sulfonamides was achieved by the addition of perchloric acid as a chaotropic agent to the extraction medium. Quality by Design framework was applied to develop and optimize both of SALLME and HPLC steps to ensure procedure robustness and sensitivity. Tolerance interval modeling of SALLME responses was applied to construct the design space of SALLME procedure. The optimized HPLC system enabled fast, sensitive and robust separation the extracted compounds within four minutes. The method detection limits of the method were in the range of 2.15-7.64 ng.mL(-1). These values were far below the guidelines recommended limits (35 and 70 ng.mL(-1) for each individual sulfonamide and trimethoprim respectively). (C) 2018 Elsevier B.V. All rights reserved.
机译：磺胺酰胺和三甲基洛姆组合已被广泛使用，以作为预防和治疗人和动物感染的抗微生物剂。尽管已经开发了许多微萃取方法用于监测环境水中的残留物，但这些方法都没有用于此目的液体微萃取。该工作呈现出同时盐辅助液 - 液微萃取SallME与HPLC-UV相结合，用于测定水样中的硫酰吡啶和六个常见的磺胺胺残基（Sulfathiazole，磺胺嗪，磺酰氨基，磺胺甲唑氧胺和磺酰喹喔啉）。通过向萃取介质中加入产氯酸来实现与磺酰胺的三甲基吡啶的共萃取。通过设计框架的质量应用于开发和优化Sallme和HPLC步骤的两种步骤，以确保程序的鲁棒性和灵敏度。扫描响应的公差间隔建模应用于构建Sallme程序的设计空间。优化的HPLC系统在四分钟内使提取的化合物快速，敏感和鲁棒分离。该方法的方法检测限度在2.15-7.64ng.ml（-1）的范围内。这些值远低于指南的推荐限制（35和70ng.ml（-1）分别为磺胺酰胺和甲肾上腺素）。 （c）2018年elestvier b.v.保留所有权利。

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