...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>World neurosurgery >Role of Cerebrospinal Fluid Markers for Predicting Shunt-Dependent Hydrocephalus in Patients with Subarachnoid Hemorrhage and External Ventricular Drain Placement
【24h】

Role of Cerebrospinal Fluid Markers for Predicting Shunt-Dependent Hydrocephalus in Patients with Subarachnoid Hemorrhage and External Ventricular Drain Placement

机译：脑脊液标志物在蛛网膜下腔出血和外心漏电下预测分流依赖性脑积水的作用

获取原文
获取原文并翻译 | 示例
   

获取外文期刊封面封底 >>

       
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

ObjectiveWe sought to identify potential risk factors for the development of shunt-dependent chronic hydrocephalus after aneurysmal subarachnoid hemorrhage (SAH) and external ventricular drain (EVD) insertion. In particular, the role of inflammatory markers within the cerebrospinal fluid (CSF) was assessed. MethodsFor this single-center analysis, data were generated from consecutive patients with SAH and the need for EVD implantation treated on our neurosurgical intensive care unit between 2013 and 2015. Parameters were patient characteristics (age, sex, comorbidity), severity of SAH (according to the World Federation of Neurological Society score), imaging findings (intraventricular hemorrhage, diameter of the third ventricle, location of the ruptured aneurysm), and acute course of disease (cerebral infarction, vasospasm). Moreover, the impact of EVD drainage volume and CSF markers (total protein [CSFTP], red blood cell count [CSFRBC], interleukin-6 [CSFIL-6], and glucose [CSFGlc]) was assessed. Statistics including receiver-operating-curve with corresponding area-under-the-curve (AUC) analysis were calculated using SPSS. ResultsOverall, 63 patients (21 males, mean age 55.2 years) were included. Twenty-one patients (30%) developed a shunt-dependent hydrocephalus. Significant risk factors for shunt dependency were the World Federation of Neurological Society score, cerebral infarction, and diameter of the third ventricle (P< 0.05). Moreover, CSF markers associated with shunt-dependent hydrocephalus included increased levels ofCSFTP on days 5 (AUC?= 0.72)/11 (AUC?= 0.97)/14 (AUC?= 0.98),CSFIL-6 on day 14 (AUC?= 0.81), andCSFRBC on day 15 (AUC?= 0.83). The EVD drainage volume was not prognostic. ConclusionsThe time course of selected inflammatory markers in CSF may support management considerations in the early phase after SAH and critical impairment of CSF circulation.
机译：目标我们试图确定动脉瘤蛛网膜下腔（SAH）和外心室排水（EVD）插入后分流依赖性慢性脑积水的潜在危险因素。特别是，评估脑脊髓液（CSF）内的炎症标志物的作用。方法对单一中心分析，数据是从连续的SAH患者生成的，以及在2013年和2015年之间对我们神经外科重症监护病房进行治疗的EVD植入。参数是患者特征（年龄，性别，合并症），SAH的严重程度（根据向世界神经学会评分联合会），成像发现（脑室出血，第三脑室的直径，破裂动脉瘤的位置），以及急性病程（脑梗塞，血管痉挛）。此外，评估EVD排水量和CSF标记的影响（总蛋白质[CSFTP]，红细胞计数[CSFRBC]，白细胞介素-6 [CSFIL-6]和葡萄糖[CSFGLC]）。使用SPSS计算包括具有相应区域曲线（AUC）分析的接收器操作曲线的统计数据。结果，63名患者（21例男性，平均55.2岁）。二十一名患者（30％）开发了分流依赖性脑积水。分流依赖性的重大风险因素是世界神经学会评分，脑梗塞和第三脑室直径的联合会（P <0.05）。此外，与分流依赖性脑积相关的CSF标记包括在第5天（AUC？= 0.72）/ 11（AUC？= 0.97）/ 14（AUC？= 0.98），CSFIL-6时（AUC？= 0.81），ANDCSFRBC在第15天（AUC？= 0.83）。 EVD排水量不是预后。结论CSF中所选炎症标志物的时间过程可能支持SAH后早期阶段的管理考虑，以及CSF流通的批判性损害。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号