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首页> 外文期刊>Journal of Materials Science >The potential of electrospun poly(methyl methacrylate)/polycaprolactone core-sheath fibers for drug delivery applications
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The potential of electrospun poly(methyl methacrylate)/polycaprolactone core-sheath fibers for drug delivery applications

机译：用于药物递送应用的电纺聚（甲基丙烯酸甲酯）/聚己内酯芯鞘纤维的电位

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Drug-loaded core-sheath fibers were successfully prepared from a combination of poly(methyl methacrylate) (PMMA) and polycaprolactone (PCL) using a coaxial electrospinning system and Nimesulide as an anti-inflammatory drug model. An electric field potential of 7-8kV was found optimal for the formation of the fibers, which were characterized using scanning and transmission electron microscopy techniques combined with attenuated total reflectance infrared spectroscopy and contact angle measurements. Results confirmed the core-sheath morphology and indicated that these fibers are larger in diameter than normal ones (prepared as controls from either PCL or PMMA, under similar conditions). The prepared core-sheath fibers were also investigated by differential scanning calorimetry and thermogravimetric analysis, and results indicated that Nimesulide is completely solubilized in the polymer matrix and that its presence improved the thermal stability of the core-sheath fibers compared to that of normal PMMA fibers. Moreover, PMMA-PCL core-sheath fibers showed an improvement in terms of mechanical properties (such as elongation at break) in comparison with pure PMMA fibers. Drug release studies demonstrated that the delivery of Nimesulide can be modulated by appropriately selecting the loading area, with faster release observed when the drug was located in the sheath. Results suggest altogether the significant potential of PMMA-PCL core-sheath fibers for applications involving delivery of hydrophobic anti-inflammatory drugs such as Nimesulide.
机译：已成功地从使用同轴静电系统和尼美舒利作为抗炎药模型的聚（甲基丙烯酸甲酯）（PMMA）和聚己内酯（PCL）的组合制备载药芯鞘纤维。 7-8kV的电场电位被发现最适合于形成纤维的，使用扫描和透射电子显微技术与衰减全反射红外光谱和接触角测量结合其进行了表征。结果证实了皮芯型的形态，并表示这些纤维的直径比正常的大得多（从任一PCL或PMMA编写的控件，类似的条件下）。将制得的芯鞘纤维也通过差示扫描量热和热重分析调查，结果表明，尼美舒利是在聚合物基质中完全溶解，并且它的存在改进了芯鞘纤维的热稳定性相比，正常PMMA纤维。此外，PMMA-PCL芯鞘纤维与纯PMMA纤维相比显示出机械性能（如断裂伸长率）的方面的改进。药物释放的研究表明，尼美舒利的递送可以通过适当地选择负载区域进行调制，当所述药物位于所述鞘较快的释放遵守。结果共表明PMMA-PCL芯鞘纤维涉及的疏水性抗炎药交付应用，如尼美舒利的显著潜力。

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