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首页> 外文期刊>Journal of Materials Science >A novel polyurethane modified with biomacromolecules for small-diameter vascular graft applications
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A novel polyurethane modified with biomacromolecules for small-diameter vascular graft applications

机译：用BioMacromoLumoLums用于小直径血管移植应用的新型聚氨酯

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摘要

There is a growing demand for small-caliber tissue-engineered vascular grafts to replace damaged vessels. Fabricated scaffolds are unable to precisely mimic the mechanical properties of native vessels, provide long-term patency and support cell adhesion and growth, in particular support endothelialization. In this study, a new biodegradable poly(ether ester urethane) urea (PEEUU) was synthesized. The synthesized polyurethane was then functionalized by introducing free amino groups through aminolysis for further surface modification by immobilization of biomacromolecules on the surface of vascular grafts. The modified surfaces were then characterized using attenuated total reflectance-Fourier transform infrared spectroscopy, water contact angle measurement and atomic force microscopy. The mechanical properties of the fabricated scaffolds were analyzed, revealing mechanical properties close to that of the natural vessels. Surface modifications led to improved cell-scaffold interactions, showing appropriate cell attachment and function on the scaffolds. A confluent layer of endothelial cells was formed on biomacromolecule-immobilized PEEUU vascular grafts. The preliminary results of this study demonstrated that the new polyurethane modified with biomacromolecules can be considered as a candidate material for vascular tissue engineering application with capability to support endothelialization of fabricated vascular grafts.
机译：对小口径组织工程血管移植物不断增长的需求，以取代受损的血管。制造的支架无法精确模仿本地容器的机械性能，提供长期通畅和支持细胞粘附和生长，特别是支持内皮化。在该研究中，合成了一种新的可生物降解的聚（醚酯氨基甲酸酯）尿素（PEEUU）。然后通过通过在血管移植物表面上固定生物致摩擦，通过氨基溶液引入游离氨基来官能化合成的聚氨酯。然后使用衰减的总反射率 - 傅里叶变换红外光谱，水接触角测量和原子力显微镜进行改性表面。分析了制造的支架的机械性能，揭示了靠自然血管的机械性能。表面改性导致改善细胞支架相互作用，显示适当的细胞附着和在支架上的功能。在生物致摩洛固定的Peeuu血管移植物上形成汇合内皮细胞层。本研究的初步结果证明，用生物致摩洛分布改性的新型聚氨酯可以被认为是用于血管组织工程应用的候选材料，其具有支持制造的血管移植物的内皮化。

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  • 来源
    《Journal of Materials Science》 |2018年第14期|共15页
  • 作者

    Asadpour Shiva; Yeganeh Hamid; Ai Jafar; Ghanbari Hossein;

  • 作者单位

    Univ Tehran Med Sci Sch Adv Technol Med Dept Tissue Engn &

    Appl Cell Sci Tehran Iran;

    Iran Polymer &

    Petrochem Inst POB 14965-115 Tehran 14977 Iran;

    Univ Tehran Med Sci Sch Adv Technol Med Dept Tissue Engn &

    Appl Cell Sci Tehran Iran;

    Univ Tehran Med Sci Sch Adv Technol Med Dept Med Nanotechnol Regenerat Nanomed Res Grp Tehran Iran;

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 工程材料学;
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