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首页> 外文期刊>Journal of Materials Science >Porous poly(L-lactic acid) nanocomposite scaffolds with functionalized TiO2 nanoparticles: properties, cytocompatibility and drug release capability
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Porous poly(L-lactic acid) nanocomposite scaffolds with functionalized TiO2 nanoparticles: properties, cytocompatibility and drug release capability

机译：具有官能化TiO2纳米颗粒的多孔聚（L-乳酸）纳米复合支架：性质，细胞组分和药物释放能力

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摘要

Cytocompatibility is one of the most important aspects in evaluating biomaterials for tissue engineering applications. In this study, biodegradable polymer scaffolds based on nanocomposites of poly(l-lactic acid) and TiO2 nanoparticles functionalized with oleic acid (5 and 10 wt%) were prepared by thermally induced phase separation method. The aim of this research was to evaluate the properties of nanocomposite scaffolds and to investigate the influence of functionalized nanofiller on their bioactivity, biodegradability and cytocompatibility. The nanocomposite scaffolds showed bioactivity in supersaturated fluids and reduced biodegradation in simulated body fluid when compared to pure PLA scaffold. Cell viability and proliferation potential in contact with nanocomposite scaffolds were tested via MTT assay, while the scaffolds cytotoxic potential was evaluated using lactate dehydrogenase method. It was found that incorporation of functionalized TiO2 nanofiller with content of 5 wt% in the corresponding PLA matrix has a significant positive effect on the cell viability and proliferation, while at higher nanofiller content (10 wt%), insignificant cell proliferation and increased cytotoxicity were confirmed. Furthermore, PLA/TiO2-OA nanocomposite scaffolds were proved as promising materials for drug delivery.
机译：细胞偶联是评估组织工程应用的生物材料中最重要的方面之一。在该研究中，通过热诱导的相分离方法制备基于聚（L-乳酸）和具有油酸（5和10wt％）的聚（L-乳酸）和TiO2纳米颗粒的纳米复合材料的可生物降解的聚合物支架。该研究的目的是评估纳米复合支架支架的性质，并研究官能化纳米填料对其生物活性，生物降解性和细胞相容性的影响。与纯PLA支架相比，纳米复合支架在超饱和流体中显示出在过饱和流体中的生物降解，并在模拟体液中降低生物降解。通过MTT测定测试与纳米复合支架接触的细胞活力和增殖电位，同时使用乳酸脱氢酶方法评价支架细胞毒性电位。发现，在相应的PLA基质中掺入官能化的TiO2纳米氧化物在相应的PLA基质中的含量为5wt％，对细胞活力和增殖具有显着的阳性作用，而在较高的纳米填充物含量（10wt％），微不足道的细胞增殖和增加的细胞毒性确认的。此外，证明了PLA / TiO2-OA纳米复合支架被证明是用于药物递送的有希望的材料。

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  • 来源
    《Journal of Materials Science》 |2018年第16期|共16页
  • 作者

    Buzarovska Aleksandra; Dinescu Sorina; Chitoiu Leona; Costache Marieta;

  • 作者单位

    Sts Cyril &

    Methodius Univ Fac Technol &

    Met Rudjer Boskovic 16 Skopje 1000 Macedonia;

    Univ Bucharest Dept Biochem &

    Mol Biol Spl Independentei 91-95 Bucharest 050095 Romania;

    Univ Bucharest Dept Biochem &

    Mol Biol Spl Independentei 91-95 Bucharest 050095 Romania;

    Univ Bucharest Dept Biochem &

    Mol Biol Spl Independentei 91-95 Bucharest 050095 Romania;

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 工程材料学;
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